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A combined model based on radiomics features of Sonazoid contrast-enhanced ultrasound in the Kupffer phase for the diagnosis of well-differentiated hepatocellular carcinoma and atypical focal liver lesions: a prospective, multicenter study

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资源类型：
Pubmed体系：
作者：
Wang Zhen[1,2] * ; Yao Jundong[2,13] ; Jing Xiang[3] ; Li Kaiyan[4] ; Lu ShiChun[5] ; Yang Hong[6] ; Ding Hong[7] ; Li Kai[8] ; Cheng Wen[9] ; He Guangzhi[10] ; Jiang Tianan[11] ; Liu Fangyi[2] ; Yu Jie[2] ; Han Zhiyu[12] ; Cheng Zhigang[12] ; Tan Shuilian[12] ; Wang Zhen[12] ; Qi Erpeng[12] ; Wang Shuo[2] ; Zhang YiQiong[2] ; Li Lu[1,2] ; Dong Xiaocong[2] ; Liang Ping[12] ; Yu Xiaoling[2] ;
单位： [1]Medical School of Chinese PLA, 28 Fuxing Road, Beijing 100853, China [2]Department of Interventional Ultrasound, First Medical Center of Chinese, PLA General Hospital, No.28 Fuxing Road, Beijing 100853, China [3]Department of Ultrasound, Tianjin Third Central Hospital, Tianjin, China [4]Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [5]Department of Hepatobiliary Surgery, The First Medical Centre, Chinese PLA General Hospital, Beijing, China [6]Department of Medical Ultrasonics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China [7]Department of Ultrasound, Huashan Hospital, Fudan University, Shanghai, China [8]Department of Ultrasound, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China [9]Department of Ultrasonography, Harbin Medical University Cancer Hospital, Harbin, China [10]Department of Ultrasound, University of Chinese Academy of Sciences Shenzhen Hospital, Guangming District, Shenzhen, China [11]Department of Ultrasound Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China [12]Department of Interventional Ultrasound, Fifth Medical Center of Chinese, PLA General Hospital, Beijing, China [13]Department of Ultrasound, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471000, China
出处：
DOI： 10.1007/s00261-024-04253-4
ISSN：

关键词： Contrast-enhanced ultrasound Sonazoid Kupffer phase Focal liver lesion

摘要：
The objective of this study was to develop a combined model based on radiomics features of Sonazoid contrast-enhanced ultrasound (CEUS) during the Kupffer phase and to evaluate its value in differentiating well-differentiated hepatocellular carcinoma (w-HCC) from atypical benign focal liver lesions (FLLs).A total of 116 patients with preoperatively Sonazoid-CEUS confirmed w-HCC or benign FLL were selected from a prospective multiple study on the clinical application of Sonazoid in FLLs conducted from August 2020 to March 2021. According to the randomization principle, the patients were divided into a training cohort and a test cohort in a 7:3 ratio. Seventy-nine patients were used for establishing and training the radiomics model and combined model. In comparison, 37 patients were used for validating and comparing the performance of the models. The diagnostic efficacy of the models for w-HCC and atypical benign FLLs was evaluated using ROCs curves and decision curves. A combined model nomogram was created to assess its value in reducing unnecessary biopsies.Among the patients, there were 55 cases of w-HCC and 61 cases of atypical benign FLLs, including 28 cases of early liver abscess, 16 cases of atypical hepatic hemangioma, 8 cases of hepatocellular dysplastic nodules (DN), and 9 cases of focal nodular hyperplasia (FNH). The radiomics model and combined model we established had AUCs of 0.905 and 0.951, respectively, in the training cohort, and the AUCs of the two models in the test cohort were 0.826 and 0.912, respectively. The combined model outperformed the radiomics feature model significantly. Decision curve analysis demonstrated that the combined model achieved a higher net benefit within a specific threshold probability range (0.25 to 1.00). A nomogram of the combined model was developed.The combined model based on the radiomics features of Sonazoid-CEUS in the Kupffer phase showed satisfactory performance in diagnosing w-HCC and atypical benign FLLs. It can assist clinicians in timely detecting malignant FLLs and reducing unnecessary biopsies for benign diseases.© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

基金：
This work was supported by Grants 82172027 from the National Scientific Foundation Committee of China.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 3 区 医学
小类 | 3 区 核医学
最新[2025]版：
大类 | 3 区 医学
小类 | 4 区 核医学
第一作者：
第一作者单位： [1]Medical School of Chinese PLA, 28 Fuxing Road, Beijing 100853, China [2]Department of Interventional Ultrasound, First Medical Center of Chinese, PLA General Hospital, No.28 Fuxing Road, Beijing 100853, China
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Zhen,Yao Jundong,Jing Xiang,et al.A combined model based on radiomics features of Sonazoid contrast-enhanced ultrasound in the Kupffer phase for the diagnosis of well-differentiated hepatocellular carcinoma and atypical focal liver lesions: a prospective, multicenter study[J].Abdominal Radiology (New York).2024,doi:10.1007/s00261-024-04253-4.
APA：
Wang Zhen,Yao Jundong,Jing Xiang,Li Kaiyan,Lu ShiChun...&Yu Xiaoling.(2024).A combined model based on radiomics features of Sonazoid contrast-enhanced ultrasound in the Kupffer phase for the diagnosis of well-differentiated hepatocellular carcinoma and atypical focal liver lesions: a prospective, multicenter study.Abdominal Radiology (New York),,
MLA：
Wang Zhen,et al."A combined model based on radiomics features of Sonazoid contrast-enhanced ultrasound in the Kupffer phase for the diagnosis of well-differentiated hepatocellular carcinoma and atypical focal liver lesions: a prospective, multicenter study".Abdominal Radiology (New York) .(2024)

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