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Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos

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收录情况： ◇ 自然指数

作者：
Zhou Bingyan[1,10] * ; Feng Chenzhao[2,3] * ; Sun Song[4] * ; Chen Xuyong[1,10] ; Zhuansun Didi[1,10] ; Wang Di[1,10] ; Yu Xiaosi[1,10] ; Meng Xinyao[1,10] ; Xiao Jun[1,10] ; Wu Luyao[1,10] ; Wang Jing[1,10] ; Wang Jing[1,10] ; Chen Ke[1,10] ; Li Zejian[1,10] ; You Jingyi[1,10] ; Mao Handan[1,10] ; Yang Shimin[1,10] ; Zhang Jiaxin[1,10] ; Jiao Chunlei[1,10] ; Li Zhi[1,10] ; Yu Donghai[1,10] ; Wu Xiaojuan[1,10] ; Zhu Tianqi[1,10] ; Yang Jixin[1,10] ; Xiang Lei[1,10] ; Liu Jiazhe[5] ; Chai Tailiang[5] ; Shen Juan[5] ; Mao Chuan-Xi[6] ; Hu Juncheng[6] ; Hao Xingjie[7] ; Xiong Bo[8,9] ; Zheng Shan[4] ; Liu Zhihua[6] ; Feng Jiexiong[1,10] ;
单位： [1]Department of Pediatric Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China [2]Department of Gynecological Oncology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China [3]National Clinical Research Center for Obstetrics and Gynecology,Cancer Biology Research Center (Key Laboratory of the Ministry of Education),Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China. [4]Department of Pediatric Surgery, Shanghai Key Laboratory of Birth Defect, Children's Hospital of Fudan University, Ministry of Health, Shanghai 201102, China. [5]BGI-Shenzhen, Shenzhen, Guangdong 518081, China. [6]State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, China. [7]Department of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. [8]Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China [9]Institute for Brain Research, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. [10]Hubei Clinical Center of Hirschsprung's Disease and Allied Disorders, Wuhan, Hubei 430030, China.
出处：
DOI： 10.1016/j.devcel.2024.03.034
ISSN：

摘要：
During enteric nervous system (ENS) development, pioneering wavefront enteric neural crest cells (ENCCs) initiate gut colonization. However, the molecular mechanisms guiding their specification and niche interaction are not fully understood. We used single-cell RNA sequencing and spatial transcriptomics to map the spatiotemporal dynamics and molecular landscape of wavefront ENCCs in mouse embryos. Our analysis shows a progressive decline in wavefront ENCC potency during migration and identifies transcription factors governing their specification and differentiation. We further delineate key signaling pathways (ephrin-Eph, Wnt-Frizzled, and Sema3a-Nrp1) utilized by wavefront ENCCs to interact with their surrounding cells. Disruptions in these pathways are observed in human Hirschsprung's disease gut tissue, linking them to ENS malformations. Additionally, we observed region-specific and cell-type-specific transcriptional changes in surrounding gut tissues upon wavefront ENCC arrival, suggesting their role in shaping the gut microenvironment. This work offers a roadmap of ENS development, with implications for understanding ENS disorders.Copyright © 2024 Elsevier Inc. All rights reserved.

基金：
This work was funded by the National Natural Science Foundation of China (82071685 and 81873541), the Horizontal issues (2020076), and the Clinical Research Pilot Project of Tongji Hospital (2019YBKY026).
语种：
外文
PubmedID：
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出版当年[2023]版：
大类 | 1 区 生物学
小类 | 1 区 细胞生物学 1 区 发育生物学
最新[2025]版：
大类 | 1 区 生物学
小类 | 1 区 细胞生物学 1 区 发育生物学
第一作者：
第一作者单位： [1]Department of Pediatric Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China [10]Hubei Clinical Center of Hirschsprung's Disease and Allied Disorders, Wuhan, Hubei 430030, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Pediatric Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China [10]Hubei Clinical Center of Hirschsprung's Disease and Allied Disorders, Wuhan, Hubei 430030, China.
推荐引用方式(GB/T 7714)：
Zhou Bingyan,Feng Chenzhao,Sun Song,et al.Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos[J].Developmental Cell.2024,doi:10.1016/j.devcel.2024.03.034.
APA：
Zhou Bingyan,Feng Chenzhao,Sun Song,Chen Xuyong,Zhuansun Didi...&Feng Jiexiong.(2024).Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos.Developmental Cell,,
MLA：
Zhou Bingyan,et al."Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos".Developmental Cell .(2024)

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