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Urinary haloacetic acid concentrations and thyroid function among women: Results from the TREE study

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资源类型：
Pubmed体系：
作者：
Wu Yang[1,2] * ; Deng Yan-Ling[1,2] ; Zhang Min[1,2] ; Miao Yu[1,2] ; Cui Fei-Peng[1,2] ; Zeng Jia-Yue[1,2] ; Liu Xiao-Ying[1,2] ; Li Cheng-Ru[1,2] ; Liu A-Xue[1,2] ; Zhu Jin-Qin[1,2] ; Li Yang-Juan[1,2,3] ; Liu Chong[4,*1] ; Zeng Qiang[1,2,*1] ;
单位： [1]Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China [2]Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China [3]Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095, Jiefang Avenue, Wuhan, Hubei, PR China [4]Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
出处：
DOI： 10.1016/j.scitotenv.2024.172368
ISSN：

关键词： Dichloroacetic acid Disinfection by-products Trichloroacetic acid Thyroid function Thyrotropin

摘要：
Disinfection byproducts (DBPs) have been shown to impair thyroid function in experimental models. However, epidemiological evidence is scarce.This study included 1190 women undergoing assisted reproductive technology (ART) treatment from the Tongji Reproductive and Environmental (TREE) cohort from December 2018 to August 2021. Serum thyrotropin (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were measured as indicators of thyroid function. FT4/FT3 and TSH/FT4 ratios were calculated as markers of thyroid hormone homeostasis. Dichloroacetic acid (DCAA) and trichloroacetic acid (TCAA), the two most abundant HAAs, in urine were detected to assess individual DBP exposures.After adjusting for relevant covariates, positive associations were observed between urinary TCAA concentrations and serum TSH and TSH/FT4 levels (e.g., percent change = 5.82 %, 95 % CI: 0.70 %, 11.21 % for TSH), whereas inverse associations were found for serum FT3 and FT4 (e.g., percent change = -1.29 %, 95 % CI: -2.49 %, -0.07 % for FT3). There also was a negative association between urinary DCAA concentration and serum FT4/FT3 (percent change = -2.49 %, 95 % CI: -4.71 %, -0.23 %). These associations were further confirmed in the restricted cubic spline and generalized additive models with linear or U-shaped dose-response relationships.Urinary HAAs were associated with altered thyroid hormone homeostasis among women undergoing ART treatment.Copyright © 2024 Elsevier B.V. All rights reserved.

基金：
This research was supported by grants from National Key Research and Development Program of China (No. 2018YFC1004201) and the National Natural Science Foundation of China (No. 81872585).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 环境科学与生态学
小类 | 1 区 环境科学
最新[2025]版：
大类 | 2 区 环境科学与生态学
小类 | 2 区 环境科学
第一作者：
第一作者单位： [1]Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China [2]Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China
通讯作者：
通讯机构： [1]Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China [2]Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China [4]Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [*1]Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
推荐引用方式(GB/T 7714)：
Wu Yang,Deng Yan-Ling,Zhang Min,et al.Urinary haloacetic acid concentrations and thyroid function among women: Results from the TREE study[J].The Science Of The Total Environment.2024,927:172368.doi:10.1016/j.scitotenv.2024.172368.
APA：
Wu Yang,Deng Yan-Ling,Zhang Min,Miao Yu,Cui Fei-Peng...&Zeng Qiang.(2024).Urinary haloacetic acid concentrations and thyroid function among women: Results from the TREE study.The Science Of The Total Environment,927,
MLA：
Wu Yang,et al."Urinary haloacetic acid concentrations and thyroid function among women: Results from the TREE study".The Science Of The Total Environment 927.(2024):172368

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