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Identifying flaws in the GWAS datasets of a published Mendelian randomization study: complementary re-evaluation and suggestion for analytical refinements

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单位： [1]Department and Institute of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,No.1095 Jiefang Avenue,Wuhan 430030,China

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In “Mendelian randomization and transcriptomic analysis reveal an inverse causal relationship between Alzheimer’s disease and cancer”, Zehua Dong and colleagues discovered a general protective efect of Alzheimer’s disease (AD) on cancer. However, after searching in a widely used GWAS database, IEU Open GWAS (https://gwas. mrcieu.ac.uk/) [1], we found several incorrect GWAS datasets were employed: ebi-a-GCST005921 [2] was used as exposure dataset for AD, which is actually “family history of AD”; furthermore, ukb-b-17001 and ukb-a-296 actually represent “ever had bowel cancer screening”, which were used as outcome datasets for bowel cancer (Fig. 1). Apparently, the authors used the incorrect GWAS datasets and did not explain for it. However, with a high heritability (60-80%), AD does have a strong correlation with AD family history [3].

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大类 | 2 区

医学

小类 | 2 区医学：研究与实验

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大类 | 2 区

医学

小类 | 2 区医学：研究与实验

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Q1 MEDICINE, RESEARCH & EXPERIMENTAL

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Q1 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 6.1 最新[2023版] 6.3 最新五年平均 7.4 出版当年[2022版] 6.9 出版当年五年平均 8.448 出版前一年[2021版] 6.1 出版后一年[2023版]

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第一作者单位： [1]Department and Institute of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,No.1095 Jiefang Avenue,Wuhan 430030,China

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