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The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy

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单位： [1]Tulane University School of Medicine, New Orleans, LA, 70112, USA. [2]Louisiana State University School of Medicine, New Orleans, LA, 70112, USA. [3]Department of Ophthalmology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei province,P.R. China. [4]Department of Cell and Molecular Biology, Tulane University, New Orleans, LA, 70118, USA. [5]Department of Ophthalmology, Tulane University, New Orleans, LA, 70112, USA. [6]Tulane Personalized Health Institute, Tulane University, New Orleans, LA, 70112, USA.

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关键词： Ocular Eye disease Angiogenesis Long noncoding RNA (lncRNA)

摘要：

Long noncoding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides in length that do not code for proteins. Initially considered a genomic mystery, an increasing number of lncRNAs have been shown to have vital roles in physiological and pathological conditions by regulating gene expression through diverse mechanisms depending on their subcellular localization. Dysregulated angiogenesis is responsible for various vascular oculopathies, including diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration, and corneal neovascularization. While anti-VEGF treatment is available, it is not curative, and long-term outcomes are suboptimal, and some patients are unresponsive. To better understand these diseases, researchers have investigated the role of lncRNAs in regulating angiogenesis and models of vascular oculopathies. This review summarizes recent research on lncRNAs in ocular angiogenesis, including the pro-angiogenic lncRNAs ANRIL, HOTAIR, HOTTIP, H19, IPW, MALAT1, MIAT, NEAT1, and TUG1, the anti-angiogenic lncRNAs MEG3 and PKNY, and the human/primate specific lncRNAs lncEGFL7OS, discussing their functions and mechanisms of action in vascular oculopathies.© 2024. The Author(s).

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出版当年[2023]版：

大类 | 2 区生物学

小类 | 2 区生化与分子生物学

最新[2025]版：

大类 | 2 区

生物学

小类 | 2 区生化与分子生物学

JCR分区：

出版当年[2022]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 6.1 最新[2023版] 7 最新五年平均 7.5 出版当年[2022版] 7.9 出版当年五年平均 9.597 出版前一年[2021版] 6.1 出版后一年[2023版]

第一作者：

第一作者单位： [1]Tulane University School of Medicine, New Orleans, LA, 70112, USA.

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通讯作者：

通讯机构： [4]Department of Cell and Molecular Biology, Tulane University, New Orleans, LA, 70118, USA. [5]Department of Ophthalmology, Tulane University, New Orleans, LA, 70112, USA. [6]Tulane Personalized Health Institute, Tulane University, New Orleans, LA, 70112, USA.

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The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy

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