Green Decoration of Silver Nanoparticles on Hydroxymethylated Lignin-Modified Magnetic Nanoparticles Using Cydonia oblonga Flower Extract: Evaluating of Its Catalytic, Antioxidant and Cytotoxic Effects Against 6 Thyroid Cancer Cell Lines
单位：[1]General Surgery Department, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Taiyuan 030032, Shanxi, China[2]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China华中科技大学同济医学院附属同济医院
We herein described a biogenic route for the in situ supporting silver nanoparticles on hydroxymethylated lignin (HL) coated Fe3O4 (iron oxide) magnetic nanoparticles using the Cydonia oblonga flower extract (Fe3O4@HL/Ag NPs) and its catalytic activity in the acetylation of alcohols and subsequent its biological activity are investigated. The successful fabrication of Fe3O4@HL/Ag NPs was established by using advanced analytical techniques such as Fourier Transformed Infra-Red spectroscopy, Transmission Electron Microscopy, Field Emission Scanning Electron Microscopy, Energy Dispersive X-ray spectroscopy, elemental mapping and Vibrating Sample Magnetization. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay was used to measure anti-thyroid cancer (on WRO, FTC133, BCPAP, TPC1, K1, and 8505C cells) properties of Fe3O4@HL/Ag NPs nanocomposite. The findings indicate that in 3 days, the cancer cell survival percentage in various dilations reduced as much as the Fe3O4@HL/Ag NPs nanocomposite concentration increased. The best anticancer effect was reported at 1000 mu g/ml dilation. MTT findings reveal that IC50 = 146, 181, 250, 141, 170, and 125 mu g/ml is a Fe3O4@HL/Ag NPs nanocomposite concentration in which 50% of the WRO, FTC133, BCPAP, TPC1, K1, and 8505C thyroid carcinoma cells. The results indicated that these Fe3O4@HL/Ag NPs nanocomposite could inhibit thyroid cancer cells more strongly than normal cells. Fe3O4@HL/Ag NPs nanocomposite shows high antioxidant effects against DPPH.
基金：
Shanxi Province 136 Revitalization Medical Project Construction Funds; Scientific Research Project of Shanxi Provincial Health Commission [2023047]
第一作者单位：[1]General Surgery Department, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Taiyuan 030032, Shanxi, China[2]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
通讯作者：
通讯机构：[1]General Surgery Department, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Taiyuan 030032, Shanxi, China[2]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
推荐引用方式(GB/T 7714)：
Ma Peng.Green Decoration of Silver Nanoparticles on Hydroxymethylated Lignin-Modified Magnetic Nanoparticles Using Cydonia oblonga Flower Extract: Evaluating of Its Catalytic, Antioxidant and Cytotoxic Effects Against 6 Thyroid Cancer Cell Lines[J].JOURNAL OF POLYMERS AND THE ENVIRONMENT.2024,doi:10.1007/s10924-024-03201-z.
APA：
Ma, Peng.(2024).Green Decoration of Silver Nanoparticles on Hydroxymethylated Lignin-Modified Magnetic Nanoparticles Using Cydonia oblonga Flower Extract: Evaluating of Its Catalytic, Antioxidant and Cytotoxic Effects Against 6 Thyroid Cancer Cell Lines.JOURNAL OF POLYMERS AND THE ENVIRONMENT,,
MLA：
Ma, Peng."Green Decoration of Silver Nanoparticles on Hydroxymethylated Lignin-Modified Magnetic Nanoparticles Using Cydonia oblonga Flower Extract: Evaluating of Its Catalytic, Antioxidant and Cytotoxic Effects Against 6 Thyroid Cancer Cell Lines".JOURNAL OF POLYMERS AND THE ENVIRONMENT .(2024)
