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Isocitrate dehydrogenase 2 regulates the proliferation of triple-negative breast cancer through the ferroptosis pathway

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单位： [1]Department of Thyroid and Breast Surgery, Hubei General Hospital, Renmin Hospital of Wuhan University, Wuhan 430000, China. [2]Department of Thyroid and Breast Surgery, Yichang Central People’s Hospital, The First Clinical College of Three Gorges University, Yichang 443000, China. [3]The First Clinical College of Three Gorges University, Yichang 443000, China. [4]Yichang Central People’s Hospital, The First Clinical College of Three Gorges University, Yichang 443000, China. [5]Department of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig-University Giessen, 35390 Giessen, Germany. [6]Department of Thyroid and Breast Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430000, China. [7]Department of Breast Surgery, Hubei Cancer Hospital, Huazhong University of Science and Technology, Wuhan 430000, China

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关键词： Ferroptosis Triple-negative breast cancer Proliferation IDH2

摘要：

Triple-negative breast cancer (TNBC) is currently the type of breast cancer with the worst prognosis; it lacks specific treatments, such as ER/PR antagonistic endocrine and anti-HER2 targeted therapies. Although immunotherapy with immune checkpoints has shown some efficacy in many solid tumors, clinical data in TNBC suggest significant limitations. The essence of ferroptosis is the impaired metabolism of intracellular lipid oxides, which in turn causes the activation and abnormalities of the immune system, including ROS, and not only plays an important role in liver injury and organ aging but also a large amount of data points to the close correlation between the ferroptosis process and tumor development. In this study, through the analysis of large-throughput biological data of breast tumors, combined with the characteristics of the biological process of ferroptosis, the specific gene IDH2 was found to be significantly highly expressed in TNBC and functionally correlated with ferroptosis. Through clinical specimens validated at the gene and protein levels, in vitro tumor cell line validation, and in vivo mouse models, we found that the high expression of IDH2 in TNBC has a role in inhibiting the ferroptosis process in TNBC, thus promoting the proliferation of TNBC cells and other malignant features.© 2024. The Author(s).

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出版当年[2023]版：

大类 | 2 区综合性期刊

小类 | 2 区综合性期刊

最新[2025]版：

大类 | 3 区综合性期刊

小类 | 3 区综合性期刊

第一作者：

第一作者单位： [1]Department of Thyroid and Breast Surgery, Hubei General Hospital, Renmin Hospital of Wuhan University, Wuhan 430000, China. [2]Department of Thyroid and Breast Surgery, Yichang Central People’s Hospital, The First Clinical College of Three Gorges University, Yichang 443000, China. [3]The First Clinical College of Three Gorges University, Yichang 443000, China.

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Isocitrate dehydrogenase 2 regulates the proliferation of triple-negative breast cancer through the ferroptosis pathway

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