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Multiomics insights into the female reproductive aging

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资源类型：
Pubmed体系：
作者：
Wei Simin[1,2,3] * ; Tang Weicheng[1,2,3] ; Chen Dan[1,2,3] ; Xiong Jiaqiang[4] ; Xue Liru[1,2,3] ; Dai Yun[1,2,3] ; Guo Yican[1,2,3] ; Wu Chuqing[1,2,3] ; Dai Jun[1,2,3,*1] ; Wu Meng[1,2,3,*1] ; Wang Shixuan[1,2,3,*1] ;
单位： [1]Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [2]National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, China [3]Ministry of Education, Key Laboratory of Cancer Invasion and Metastasis, Wuhan, China [4]Department of Obstetrics and Gynecology, Zhongnan Hospital, Wuhan University, Wuhan, China
出处：
DOI： 10.1016/j.arr.2024.102245
ISSN：

关键词： Female reproductive aging Multiomics Fertility Ovary Uterine Hypothalamus-pituitary axis

摘要：
The human female reproductive lifespan significantly diminishes with age, leading to decreased fertility, reduced fertility quality and endocrine function disorders. While many aspects of aging in general have been extensively documented, the precise mechanisms governing programmed aging in the female reproductive system remain elusive. Recent advancements in omics technologies and computational capabilities have facilitated the emergence of multiomics deep phenotyping. Through the application and refinement of various high-throughput omics methods, a substantial volume of omics data has been generated, deepening our comprehension of the pathogenesis and molecular underpinnings of reproductive aging. This review highlights current and emerging multiomics approaches for investigating female reproductive aging, encompassing genomics, epigenomics, transcriptomics, proteomics, metabolomics, and microbiomics. We elucidate their influence on fundamental cell biology and translational research in the context of reproductive aging, address the limitations and current challenges associated with multiomics studies, and offer a glimpse into future prospects.Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.

基金：
This work was financially supported by the National Key Research and Development Program of China (grant number 2022YFC2704100) and the National Natural Science Foundation of China (no. 82001514, 82001498, 82101703, 22104040).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 医学
小类 | 1 区 老年医学 2 区 细胞生物学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 老年医学 2 区 细胞生物学
第一作者：
第一作者单位： [1]Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [2]National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, China [3]Ministry of Education, Key Laboratory of Cancer Invasion and Metastasis, Wuhan, China
通讯作者：
通讯机构： [1]Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [2]National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, China [3]Ministry of Education, Key Laboratory of Cancer Invasion and Metastasis, Wuhan, China [*1]Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China
推荐引用方式(GB/T 7714)：
Wei Simin,Tang Weicheng,Chen Dan,et al.Multiomics insights into the female reproductive aging[J].Ageing Research Reviews.2024,95:102245.doi:10.1016/j.arr.2024.102245.
APA：
Wei Simin,Tang Weicheng,Chen Dan,Xiong Jiaqiang,Xue Liru...&Wang Shixuan.(2024).Multiomics insights into the female reproductive aging.Ageing Research Reviews,95,
MLA：
Wei Simin,et al."Multiomics insights into the female reproductive aging".Ageing Research Reviews 95.(2024):102245

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