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Mediating Effect of Tobacco Dependence on the Association Between Maternal Smoking During Pregnancy and Chronic Obstructive Pulmonary Disease: Case-Control Study

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收录情况： ◇ SCIE ◇ SSCI

作者：
Li Jinxuan[1,2,3,4,5,6,7] * ; Xu Jianying[8] ; Yang Lan[9] ; Xu Yongjian[10] ; Zhang Xiangyan[11] ; Bai Chunxue[12] ; Kang Jian[13] ; Ran Pixin[14] ; Shen Huahao[15] ; Wen Fuqiang[16] ; Huang Kewu[17] ; Yao Wanzhen[18] ; Sun Tieying[19,20] ; Shan Guangliang[21] ; Yang Ting[2,3,4,5,22] ; Lin Yingxiang[17] ; Zhu Jianguo[20] ; Wang Ruiying[8] ; Shi Zhihong[9] ; Zhao Jianping[10] ; Ye Xianwei[11] ; Song Yuanlin[12] ; Wang Qiuyue[13] ; Hou Gang[2,3,4,5,22] ; Zhou Yumin[14] ; Li Wen[15] ; Ding Liren[15] ; Wang Hao[16] ; Chen Yahong[18] ; Guo Yanfei[19,20] ; Xiao Fei[20] ; Lu Yong[17] ; Peng Xiaoxia[23,24] ; Zhang Biao[21] ; Wang Zuomin[25] ; Zhang Hong[17] ; Bu Xiaoning[17] ; Zhang Xiaolei[2,3,4,5,22] ; An Li[17] ; Zhang Shu[17] ; Cao Zhixin[17] ; Zhan Qingyuan[2,3,4,5,22] ; Yang Yuanhua[17] ; Liang Lirong[26,27] ; Cao Bin[2,3,4,5,22] ; Dai Huaping[2,3,4,5,22] ; Chung Kian Fan[28] ; Chen Zhengming[29] ; He Jiang[30] ; Wu Sinan[2,3,4,5,31] ; Xiao Dan[2,3,4,5,6,7] ; Wang Chen[2,3,4,5,7,22] ;
单位： [1]China-Japan Friendship School of Clinical Medicine, Capital Medical University, Beijing, China. [2]National Center for Respiratory Medicine, Beijing, China. [3]State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China. [4]National Clinical Research Center for Respiratory Diseases, Beijing, China. [5]Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China. [6]Department of Tobacco Control and Prevention of Respiratory Diseases, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China. [7]WHO Collaborating Centre for Tobacco Cessation and Respiratory Diseases Prevention, Beijing, China. [8]Department of Pulmonary and Critical Care Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan, China. [9]Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. [10]Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [11]Department of Pulmonary and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang, China. [12]Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. [13]Department of Pulmonary and Critical Care Medicine, First Hospital of China Medical University, Shenyang, China. [14]State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. [15]Department of Pulmonary and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. [16]State Key Laboratory of Biotherapy of China and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China. [17]Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. [18]Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing, China. [19]Department of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing, China. [20]National Center of Gerontology, Beijing, China. [21]Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China. [22]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China. [23]Center for Clinical Epidemiology and Evidence-Based Medicine, Beijing Children's Hospital, Capital Medical University, Beijing, China. [24]National Center for Children's Health, Beijing, China. [25]Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. [26]Department of Epidemiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. [27]Beijing Institute of Respiratory Medicine, Beijing, China. [28]National Heart and Lung Institute, Imperial College London and Royal Brompton and Harefield NHS Trust, London, United Kingdom. [29]Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom. [30]Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States. [31]Data and Project Management Unit, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
出处：
DOI： 10.2196/53170
ISSN：

关键词： chronic obstructive pulmonary disease tobacco dependence smoking mediating effects lung function

摘要：
Maternal smoking during pregnancy (MSDP) is a known risk factor for offspring developing chronic obstructive pulmonary disease (COPD), but the underlying mechanism remains unclear.This study aimed to explore whether the increased COPD risk associated with MSDP could be attributed to tobacco dependence (TD).This case-control study used data from the nationwide cross-sectional China Pulmonary Health study, with controls matched for age, sex, and smoking status. TD was defined as smoking within 30 minutes of waking, and the severity of TD was assessed using the Fagerstrom Test for Nicotine Dependence. COPD was diagnosed when the ratio of forced expiratory volume in 1 second to forced vital capacity was <0.7 in a postbronchodilator pulmonary function test according to the 2017 Global Initiative for Chronic Obstructive Lung Disease criteria. Logistic regression was used to examine the correlation between MSDP and COPD, adjusting for age, sex, BMI, educational attainment, place of residence, ethnic background, occupation, childhood passive smoking, residential fine particulate matter, history of childhood pneumonia or bronchitis, average annual household income, and medical history (coronary heart disease, hypertension, and diabetes). Mediation analysis examined TD as a potential mediator in the link between MSDP and COPD risk. The significance of the indirect effect was assessed through 1000 iterations of the "bootstrap" method.The study included 5943 participants (2991 with COPD and 2952 controls). Mothers of the COPD group had higher pregnancy smoking rates (COPD: n=305, 10.20%; controls: n=211, 7.10%; P<.001). TD was more prevalent in the COPD group (COPD: n=582, 40.40%; controls: n=478, 33.90%; P<.001). After adjusting for covariates, MSDP had a significant effect on COPD (β=.097; P<.001). There was an association between MSDP and TD (β=.074; P<.001) as well as between TD and COPD (β=.048; P=.007). Mediation analysis of TD in the MSDP-COPD association showed significant direct and indirect effects (direct: β=.094; P<.001 and indirect: β=.004; P=.03). The indirect effect remains present in the smoking population (direct: β=.120; P<.001 and indirect: β=.002; P=.03).This study highlighted the potential association between MSDP and the risk of COPD in offspring, revealing the mediating role of TD in this association. These findings contribute to a deeper understanding of the impact of prenatal tobacco exposure on lung health, laying the groundwork for the development of relevant prevention and treatment strategies.©Jinxuan Li, Jianying Xu, Lan Yang, Yongjian Xu, Xiangyan Zhang, Chunxue Bai, Jian Kang, Pixin Ran, Huahao Shen, Fuqiang Wen, Kewu Huang, Wanzhen Yao, Tieying Sun, Guangliang Shan, Ting Yang, Yingxiang Lin, Jianguo Zhu, Ruiying Wang, Zhihong Shi, Jianping Zhao, Xianwei Ye, Yuanlin Song, Qiuyue Wang, Gang Hou, Yumin Zhou, Wen Li, Liren Ding, Hao Wang, Yahong Chen, Yanfei Guo, Fei Xiao, Yong Lu, Xiaoxia Peng, Biao Zhang, Zuomin Wang, Hong Zhang, Xiaoning Bu, Xiaolei Zhang, Li An, Shu Zhang, Zhixin Cao, Qingyuan Zhan, Yuanhua Yang, Lirong Liang, Bin Cao, Huaping Dai, Kian Fan Chung, Zhengming Chen, Jiang He, Sinan Wu, Dan Xiao, Chen Wang, China Pulmonary Health Study Group. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 22.02.2024.

基金：
The study was funded by the Chinese Academy of Medical Sciences (CAMS) Initiative for Innovative Medicine (CAMS 2021-I2M-1-010) and the Special Research Foundation for Public Welfare of Health, Ministry of Health of China (grant 201002008).
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 2 区 公共卫生、环境卫生与职业卫生
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 公共卫生、环境卫生与职业卫生
JCR分区：
出版当年[2022]版：
Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
最新[2023]版：
Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者单位： [1]China-Japan Friendship School of Clinical Medicine, Capital Medical University, Beijing, China. [2]National Center for Respiratory Medicine, Beijing, China. [3]State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China. [4]National Clinical Research Center for Respiratory Diseases, Beijing, China. [5]Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China. [6]Department of Tobacco Control and Prevention of Respiratory Diseases, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China. [7]WHO Collaborating Centre for Tobacco Cessation and Respiratory Diseases Prevention, Beijing, China.
通讯作者：
通讯机构： [2]National Center for Respiratory Medicine, Beijing, China. [3]State Key Laboratory of Respiratory Health and Multimorbidity, Beijing, China. [4]National Clinical Research Center for Respiratory Diseases, Beijing, China. [5]Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China. [6]Department of Tobacco Control and Prevention of Respiratory Diseases, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China. [7]WHO Collaborating Centre for Tobacco Cessation and Respiratory Diseases Prevention, Beijing, China.
推荐引用方式(GB/T 7714)：
Li Jinxuan,Xu Jianying,Yang Lan,et al.Mediating Effect of Tobacco Dependence on the Association Between Maternal Smoking During Pregnancy and Chronic Obstructive Pulmonary Disease: Case-Control Study[J].JMIR PUBLIC HEALTH AND SURVEILLANCE.2024,10:e53170.doi:10.2196/53170.
APA：
Li Jinxuan,Xu Jianying,Yang Lan,Xu Yongjian,Zhang Xiangyan...&Wang Chen.(2024).Mediating Effect of Tobacco Dependence on the Association Between Maternal Smoking During Pregnancy and Chronic Obstructive Pulmonary Disease: Case-Control Study.JMIR PUBLIC HEALTH AND SURVEILLANCE,10,
MLA：
Li Jinxuan,et al."Mediating Effect of Tobacco Dependence on the Association Between Maternal Smoking During Pregnancy and Chronic Obstructive Pulmonary Disease: Case-Control Study".JMIR PUBLIC HEALTH AND SURVEILLANCE 10.(2024):e53170

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