单位：[1]Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.[2]Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.[3]Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, China.[4]The Affiliated Hospital of Luzhou Medical College, Luzhou, China.[5]The First Affiliated Hospital of Guangxi Medical University, Nanning, China.[6]Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.[7]Affiliated Hospital of Guiyang Medical University, Guiyang, China.[8]Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.[9]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.华中科技大学同济医学院附属同济医院[10]Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.中山大学附属第二医院[11]The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.[12]The First Hospital of Lanzhou University, Lanzhou, China.[13]Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China.[14]Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian, China.大连市中心医院[15]The First Hospital of Jilin University, Changchun, China.[16]The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.[17]Qilu Hospital of Shandong University, Jinan, China.[18]The Second Affiliated Hospital of Harbin Medical University, Harbin, China.[19]Central Hospital of Shanghai Jiading District, Shanghai, China.[20]Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China.江苏省人民医院[21]The First Affiliated Hospital of Anhui Medical University, Hefei, China.[22]Karamay Municipal People's Hospital, Xinjiang, China.[23]The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.江苏省人民医院[24]The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.重庆医科大学附属第一医院[25]Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.华中科技大学同济医学院附属协和医院[26]Shandong Provincial Hospital affiliated to Shandong University, Jinan, China.[27]Chinese People's Liberation Army General Hospital, Beijing, China.
: Low educational attainment is a well-established risk factor for nonalcoholic fatty liver disease (NAFLD) in developed areas. However, the association between educational attainment and the risk of NAFLD is less clear in China.: A cross-sectional study including over 200,000 Chinese adults across mainland China was conducted. Information on education level and lifestyle factors were obtained through standard questionnaires, while NAFLD and advanced fibrosis were diagnosed using validated formulas. Outcomes included the risk of NAFLD in the general population and high probability of fibrosis among patients with NAFLD. Logistic regression analysis was employed to estimate the risk of NAFLD and fibrosis across education levels. A causal mediation model was used to explore the potential mediators.: Comparing with those receiving primary school education, the multi-adjusted odds ratios (95% confidence intervals) for NAFLD were 1.28 (1.16 to 1.41) for men and 0.94 (0.89 to 0.99) for women with college education after accounting for body mass index. When considering waist circumference, the odds ratios (95% CIs) were 0.94 (0.86 to 1.04) for men and 0.88 (0.80 to 0.97) for women, respectively. The proportions mediated by general and central obesity were 51.00% and 68.04% for men, while for women the proportions were 48.58% and 32.58%, respectively. Furthermore, NAFLD patients with lower educational attainment showed an incremental increased risk of advanced fibrosis in both genders.: In China, a low education level was associated with a higher risk of prevalent NAFLD in women, as well as high probability of fibrosis in both genders.
基金：
National Natural Science Foundation of China (Grant No. 81930021, 81970728, 81970691, 81900741, 81870604, 82100916 and 21904084), Shanghai Municipal Human Resource Development Program for Outstanding Academic Leaders in Medical Disciplines (Grant No. 20XD1422800), Chinese Academy of Medical Sciences (Grant No. 2018PT32017, 2019PT330006), S Ministry of Science and Technology of China (Grant No. 2 2022YFC2505202), Clinical Research Plan of SHDC (Grant No. SHDC2020CR3064B), and Science and Technology Commission of Shanghai Municipality (Grant No. 19411964200 and 20Y11905100).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|3 区医学
小类|3 区胃肠肝病学
最新[2025]版：
大类|3 区医学
小类|3 区胃肠肝病学
第一作者：
第一作者单位：[1]Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.[2]Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.[2]Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
推荐引用方式(GB/T 7714)：
Zhu Yuanyue,Wang Long,Lin Lin,et al.The Association between Educational Attainment and the Risk of Nonalcoholic Fatty Liver Disease among Chinese Adults: Findings from the REACTION Study[J].Gut And Liver.2024,doi:10.5009/gnl230220.
APA：
Zhu Yuanyue,Wang Long,Lin Lin,Huo Yanan,Wan Qin...&Lu Jieli.(2024).The Association between Educational Attainment and the Risk of Nonalcoholic Fatty Liver Disease among Chinese Adults: Findings from the REACTION Study.Gut And Liver,,
MLA：
Zhu Yuanyue,et al."The Association between Educational Attainment and the Risk of Nonalcoholic Fatty Liver Disease among Chinese Adults: Findings from the REACTION Study".Gut And Liver .(2024)
