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Pan-cancer analysis of ABCC1 as a potential prognostic and immunological biomarker

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单位： [1]Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, China [2]Hepatic Surgery Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,China [3]Clinical Medicine Research Center for Hepatic Surgery of Hubei Province, China [4]Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Public Health, Wuhan, Hubei 430030, China. [5]Department of Gastroenterology,Institute of Liver and Gastrointestinal Diseases,Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China

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关键词： ABCC1 Pan-cancer analysis Immunity Tumor-infiltrating macrophages Prognosis Hepatocellular carcinoma

摘要：

ABCC1 belongs to the ATP-binding cassette (ABC) superfamily, which encompasses a total of 48 constituent members. ABCC1 has been shown to be associated with the growth, progression, and drug resistance of various types of cancer. However, the impact of ABCC1 on cancer immune infiltration and pan-cancer prognosis has been rarely studied. Our comprehensive pan-cancer analysis unveiled elevated ABCC1 expression across various cancers. ABCC1 overexpression consistently predicted unfavorable outcomes based on TCGA data. Moreover, ABCC1 expression exhibited intricate associations with diverse immune-related genes and demonstrated a close correlation with immune scores across multiple tumor types. Analysis of scRNA-seq data from the GEO database revealed that the expression of ABCC1 in hepatocellular carcinoma (HCC) cells is significant positively correlated with macrophage infiltration. Furthermore, various in vitro and in vivo experiments substantiated the role of ABCC1 in promoting the progression of HCC, along with increased macrophage recruitment. Based on the results, we propose ABCC1 as a potentially valuable prognostic indicator and a prospective target for immune-based cancer therapies.Copyright © 2024. Published by Elsevier Inc.

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出版当年[2023]版：

大类 | 2 区医学

小类 | 3 区肿瘤学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

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出版当年[2022]版：

Q2 ONCOLOGY

最新[2023]版：

Q1 ONCOLOGY

影响因子： 4.5 最新[2023版] 4.2 最新五年平均 5 出版当年[2022版] 4.6 出版当年五年平均 4.803 出版前一年[2021版] 4.5 出版后一年[2023版]

第一作者：

第一作者单位： [1]Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, China [2]Hepatic Surgery Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,China [3]Clinical Medicine Research Center for Hepatic Surgery of Hubei Province, China [4]Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Public Health, Wuhan, Hubei 430030, China.

通讯作者：

通讯机构： [1]Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, China [2]Hepatic Surgery Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,China [3]Clinical Medicine Research Center for Hepatic Surgery of Hubei Province, China [4]Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Public Health, Wuhan, Hubei 430030, China.

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Pan-cancer analysis of ABCC1 as a potential prognostic and immunological biomarker

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