Background: Intracerebral hemorrhage (ICH) is a stroke subtype characterized by high mortality and complex post-event complications. Research has extensively covered the acute phase of ICH; however, ICU readmission determinants remain less explored. Utilizing the MIMIC-III and MIMIC-IV databases, this investigation develops machine learning (ML) models to anticipate ICU readmissions in ICH patients.Methods: Retrospective data from 2242 ICH patients were evaluated using ICD-9 codes. Recursive feature elimination with cross-validation (RFECV) discerned significant predictors of ICU readmissions. Four ML mod-els-AdaBoost, RandomForest, LightGBM, and XGBoost-underwent development and rigorous validation. SHapley Additive exPlanations (SHAP) elucidated the effect of distinct features on model outcomes.Results: ICU readmission rates were 9.6% for MIMIC-III and 10.6% for MIMIC-IV. The LightGBM model, with an AUC of 0.736 (95% CI: 0.668-0.801), surpassed other models in validation datasets. SHAP analysis revealed hydrocephalus, sex, neutrophils, Glasgow Coma Scale (GCS), specific oxygen saturation (SpO2) levels, and creatinine as significant predictors of readmission.Conclusion: The LightGBM model demonstrates considerable potential in predicting ICU readmissions for ICH patients, highlighting the importance of certain clinical predictors. This research contributes to optimizing patient care and ICU resource management. Further prospective studies are warranted to corroborate and enhance these predictive insights for clinical utilization.
基金:
National Key Research and Development Program of China [2020YFC2006001]; National Key Research and Development Program of Hubei Province [2020BCA089]
第一作者单位:[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Neurol,1095 Jiefang Ave,Wuhan 430030,Peoples R China
通讯作者:
推荐引用方式(GB/T 7714):
Miao Jinfeng,Zuo Chengchao,Cao Huan,et al.Predicting ICU readmission risks in intracerebral hemorrhage patients: Insights from machine learning models using MIMIC databases[J].JOURNAL OF THE NEUROLOGICAL SCIENCES.2024,456:doi:10.1016/j.jns.2023.122849.
APA:
Miao, Jinfeng,Zuo, Chengchao,Cao, Huan,Gu, Zhongya,Huang, Yaqi...&Wang, Furong.(2024).Predicting ICU readmission risks in intracerebral hemorrhage patients: Insights from machine learning models using MIMIC databases.JOURNAL OF THE NEUROLOGICAL SCIENCES,456,
MLA:
Miao, Jinfeng,et al."Predicting ICU readmission risks in intracerebral hemorrhage patients: Insights from machine learning models using MIMIC databases".JOURNAL OF THE NEUROLOGICAL SCIENCES 456.(2024)