单位：[1]Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.儿科学系华中科技大学同济医学院附属同济医院
The function of the respiratory chain is closely associated with kidney function, and the dysfunction of the respiratory chain is a primary pathophysiological change in chronic kidney failure. The incidence of chronic kidney failure caused by defects in respiratory-chain-related genes has frequently been overlooked. Correcting abnormal metabolic reprogramming, rescuing the "toxic respiratory chain", and targeting the clearance of mitochondrial reactive oxygen species are potential therapies for treating chronic kidney failure. These treatments have shown promising results in slowing fibrosis and inflammation progression and improving kidney function in various animal models of chronic kidney failure and patients with chronic kidney disease (CKD). The mitochondrial respiratory chain is a key target worthy of attention in the treatment of chronic kidney failure. This review integrated research related to the mitochondrial respiratory chain and chronic kidney failure, primarily elucidating the pathological status of the mitochondrial respiratory chain in chronic kidney failure and potential therapeutic drugs. It provided new ideas for the treatment of kidney failure and promoted the development of drugs targeting the mitochondrial respiratory chain.
基金：
The work for this study was supported by National Key Scientific Research and Development Program of China (No.2022YFC2705193), National Natural Science Foundation of China
(No. 82370713) and the Key Scientific Research and Development Program of Hubei Province
(No.2022BCA047).
第一作者单位：[1]Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Yi,Yang Jing,Zhang Yu,et al.Focus on Mitochondrial Respiratory Chain: Potential Therapeutic Target for Chronic Renal Failure[J].INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2024,25(2):doi:10.3390/ijms25020949.
APA：
Wang Yi,Yang Jing,Zhang Yu&Zhou Jianhua.(2024).Focus on Mitochondrial Respiratory Chain: Potential Therapeutic Target for Chronic Renal Failure.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,25,(2)
MLA：
Wang Yi,et al."Focus on Mitochondrial Respiratory Chain: Potential Therapeutic Target for Chronic Renal Failure".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 25..2(2024)
