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Environmental Enrichment for Stroke and Traumatic Brain Injury: Mechanisms and Translational Implications

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单位： [1]Department of Pain Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. [2]Department of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan Province, China. [3]Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [4]Key Laboratory for Brain Science Research and Transformation in the Tropical Environment of Hainan Province, Hainan Medical University, Haikou, China. [5]Department of Psychology, University of Toronto, Toronto, Ontario, Canada. [6]Division of Functional Food Research, Korea Food Research Institute, Wanju-gun, Jeollabuk-do, Republic of Korea. [7]Department of Food Biotechnology, Korea University of Science & Technology, Daejeon, Republic of Korea. [8]Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo, Chiba, Japan. [9]Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India. [10]Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, Vienna, Austria. [11]Department of Neurology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.

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Acquired brain injuries, such as ischemic stroke, intracerebral hemorrhage (ICH), and traumatic brain injury (TBI), can cause severe neurologic damage and even death. Unfortunately, currently, there are no effective and safe treatments to reduce the high disability and mortality rates associated with these brain injuries. However, environmental enrichment (EE) is an emerging approach to treating and rehabilitating acquired brain injuries by promoting motor, sensory, and social stimulation. Multiple preclinical studies have shown that EE benefits functional recovery, including improved motor and cognitive function and psychological benefits mediated by complex protective signaling pathways. This article provides an overview of the enriched environment protocols used in animal models of ischemic stroke, ICH, and TBI, as well as relevant clinical studies, with a particular focus on ischemic stroke. Additionally, we explored studies of animals with stroke and TBI exposed to EE alone or in combination with multiple drugs and other rehabilitation modalities. Finally, we discuss the potential clinical applications of EE in future brain rehabilitation therapy and the molecular and cellular changes caused by EE in rodents with stroke or TBI. This article aims to advance preclinical and clinical research on EE rehabilitation therapy for acquired brain injury. © 2024 American Physiological Society. Compr Physiol 14:5291-5323, 2024.Copyright © 2024 American Physiological Society. All rights reserved.

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出版当年[2022]版：

大类 | 1 区

医学

小类 | 1 区生理学

最新[2025]版：

大类 | 2 区医学

小类 | 1 区生理学

第一作者：

第一作者单位： [1]Department of Pain Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. [2]Department of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan Province, China. [3]Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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通讯作者：

通讯机构： [1]Department of Pain Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. [2]Department of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan Province, China.

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