个人科研网厅 | | 帮助
高级检索
当前位置： 首页 > 详情页

Blocking MyD88 signaling with MyD88 inhibitor prevents colitis-associated colorectal cancer development by maintaining colonic microbiota homeostasis

| 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Xie Bin[1,2,3,4] * ; Wang Bo[5] * ; Shang Runshi[1,2,3,4] ; Wang Lu[1,2,3,4] ; Huang Xia[1,2,3,4] ; Xie Lin[1,2,3,4] ;
单位： [1]Institute of Organ Transplantation,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China. [2]Key Laboratory of Organ Transplantation, Ministry of Education, Wuhan, China. [3]NHC Key Laboratory of Organ Transplantation, Wuhan, China. [4]Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China. [5]Department of Gastroenterology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China
出处：
DOI： 10.1038/s41598-023-49457-8
ISSN：

摘要：
Certain intestinal microbiota alterations appear to positively correlate with tumorigenesis of CAC due to the disruption of the balance between the host and microorganisms. It is proven that blocking MyD88 signaling can prevent colitis-associated colorectal cancer (CAC) development in mice. We are aim to reveal the role of MyD88 signaling of maintaining colonic microbiota homeostasis for preventing CAC development. We here analyzed the landscape of gut microbiome in the mice model of AOM/DSS-induced CAC with MyD88 inhibitor treatment. PCoA revealed significant reduction in Lactobacillus load and increase in Escherichia load in the mucosal microbial composition of mice with CAC, compared with normal controls (NCs). Inhibitor-treatment led to almost undetectable Proteobacteria (Escherichia) and the retention of the dominance of Firmicutes and Bacteroidota (Muribaculaceae) in the mucosa. RNA sequencing analysis identified genes were up-regulated (Hp, SAA3 and IL-1F9) and down-regulated (CYP3A44, SLC30A10, GPNMB and OTC) in Inhibitor-treated mice (vs. CAC). Meanwhile, Inhibitor-treated mice had higher percentage of MUC2-positive area in colon sections (vs. CAC, which was less than NCs) by IF staining and decreased Escherichia in the mucus layer (vs. CAC) by FISH. And intestinal microbiota from mice with MyD88 inhibitor treatment could lessen the outcome of CAC by fecal microbiota transplantation. The development of CAC was involved in the increasing and ectopic Escherichia in the decreasing colonic mucus layer. MyD88 signaling blockade may maintain the host-microbiota homeostasis by up-regulating MUC2 production, increasing probiotics and their protective effects, and inhibiting the reproduction of Escherichia.© 2023. The Author(s).

基金：
This work was supported by the National Natural Science Foundations for Young Scientists of China (Grant # 81702817); National Natural Science Foundations of China (Grant # 82273309); the Non-Profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2019PT320014); the Hubei Provincial Natural Science Foundation of China (2021CFB401); the Hubei Province health and family planning scientific research project (WJ2023M014); and Open Project of the Key Laboratory of Organ Transplantation, Ministry of Education, and NHC (2020QYKF02).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 综合性期刊
小类 | 3 区 综合性期刊
最新[2025]版：
大类 | 3 区 综合性期刊
小类 | 3 区 综合性期刊
JCR分区：
出版当年[2021]版：
Q2 MULTIDISCIPLINARY SCIENCES
最新[2023]版：
Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者单位： [1]Institute of Organ Transplantation,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China. [2]Key Laboratory of Organ Transplantation, Ministry of Education, Wuhan, China. [3]NHC Key Laboratory of Organ Transplantation, Wuhan, China. [4]Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China.
共同第一作者：
通讯作者：
通讯机构： [1]Institute of Organ Transplantation,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China. [2]Key Laboratory of Organ Transplantation, Ministry of Education, Wuhan, China. [3]NHC Key Laboratory of Organ Transplantation, Wuhan, China. [4]Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China.
推荐引用方式(GB/T 7714)：
Xie Bin,Wang Bo,Shang Runshi,et al.Blocking MyD88 signaling with MyD88 inhibitor prevents colitis-associated colorectal cancer development by maintaining colonic microbiota homeostasis[J].SCIENTIFIC REPORTS.2023,13(1):22552.doi:10.1038/s41598-023-49457-8.
APA：
Xie Bin,Wang Bo,Shang Runshi,Wang Lu,Huang Xia&Xie Lin.(2023).Blocking MyD88 signaling with MyD88 inhibitor prevents colitis-associated colorectal cancer development by maintaining colonic microbiota homeostasis.SCIENTIFIC REPORTS,13,(1)
MLA：
Xie Bin,et al."Blocking MyD88 signaling with MyD88 inhibitor prevents colitis-associated colorectal cancer development by maintaining colonic microbiota homeostasis".SCIENTIFIC REPORTS 13..1(2023):22552

资源点击量：428 今日访问量：0 总访问量：412 更新日期：2025-04-01 建议使用谷歌、火狐浏览器 常见问题

版权所有：重庆聚合科技有限公司 渝ICP备12007440号-3 地址：重庆市两江新区泰山大道西段8号坤恩国际商务中心16层（401121）