单位：[1]Anhui Province Key Laboratory of Genitourinary Diseases, Department of Urology, The First Affiliated Hospital of Anhui Medical University, Institute of Urology, Anhui Medical University, Hefei 230022, China.[2]Key Laboratory of Organ Transplantation of Ministry of Education,Institute of Organ Transplantation,Tongji Hospital,Tongji Medical College,National Health Commission and Chinese Academy of Medical Sciences,Huazhong University of Science and Technology,Wuhan 430030,China.器官移植研究所华中科技大学同济医学院附属同济医院器官移植
X-box binding protein 1 (XBP1) is a unique basic-region leucine zipper (bZIP) transcription factor. Over recent years, the powerful biological functions of XBP1 in oxidative stress have been gradually revealed. When the redox balance remains undisturbed, oxidative stress plays a role in physiological adaptations and signal transduction. However, during the aging process, increased cellular senescence and reduced levels of endogenous antioxidants cause an oxidative imbalance in the cardiorenal system. Recent studies from our laboratory and others have indicated that these age-related cardiorenal diseases caused by oxidative stress are guided and controlled by a versatile network composed of diversified XBP1 pathways. In this review, we describe the mechanisms that link XBP1 and oxidative stress in a range of cardiorenal disorders, including mitochondrial instability, inflammation, and alterations in neurohumoral drive. Furthermore, we propose that differing degrees of XBP1 activation may cause beneficial or harmful effects in the cardiorenal system. Gaining a comprehensive understanding of how XBP1 exerts influence on the aging cardiorenal system by regulating oxidative stress will enhance our ability to provide new directions and strategies for cardiovascular and renal safety outcomes.
基金：
This work was supported by grants to NQ Gong from the National Natural Science
Foundation of China (No. 82370759 and 82170772), to NQ Gong from the Major State Basic Research
Development Program of China (No. 2013CB530803, 973), to XP Chen from the Special Project of the
Ministry of Health (No. 201302009), and to NQ Gong from the Clinical Research Physician Program
of Tongji Medical College, HUST (No. 201704).
第一作者单位：[1]Anhui Province Key Laboratory of Genitourinary Diseases, Department of Urology, The First Affiliated Hospital of Anhui Medical University, Institute of Urology, Anhui Medical University, Hefei 230022, China.[2]Key Laboratory of Organ Transplantation of Ministry of Education,Institute of Organ Transplantation,Tongji Hospital,Tongji Medical College,National Health Commission and Chinese Academy of Medical Sciences,Huazhong University of Science and Technology,Wuhan 430030,China.
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推荐引用方式(GB/T 7714)：
Zhang Ji,Zhao Yuanyuan,Gong Nianqiao.XBP1 Modulates the Aging Cardiorenal System by Regulating Oxidative Stress[J].ANTIOXIDANTS.2023,12(11):doi:10.3390/antiox12111933.
APA：
Zhang Ji,Zhao Yuanyuan&Gong Nianqiao.(2023).XBP1 Modulates the Aging Cardiorenal System by Regulating Oxidative Stress.ANTIOXIDANTS,12,(11)
MLA：
Zhang Ji,et al."XBP1 Modulates the Aging Cardiorenal System by Regulating Oxidative Stress".ANTIOXIDANTS 12..11(2023)
