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Effect of Laparoscopic and Open Pancreatoduodenectomy for Pancreatic or Periampullary Tumors: Three-year Follow-up of a Randomized Clinical Trial

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Pubmed体系：
作者：
Qin Tingting[1] * ; Zhang Hang[1] ; Pan Shutao[1] ; Liu Jun[2] ; Li Dewei[3] ; Chen Rufu[4] ; Huang Xiaobing[5] ; Liu Yahui[6] ; Liu Jianhua[7] ; Cheng Wei[8,9] ; Chen Xuemin[10] ; Zhao Wenxing[11] ; Li Jingdong[12] ; Tan Zhijian[13] ; Huang Heguang[14] ; Li Deyu[15] ; Zhu Feng[1] ; Yu Guangsheng[2] ; Zhou Baoyong[3] ; Zheng Shangyou[4] ; Tang Yichen[5] ; Ke Jianji[6] ; Liu Xueqing[7] ; Chen Botao[9] ; Chen Weibo[10] ; Ma Hongqin[11] ; Xu Jian[12] ; Liu Yifeng[13] ; Lin Ronggui[14] ; Dong Yadong[15] ; Yu Yahong[15] ; Wang Min[1,*1] ; Qin Renyi[1,*1] ;
单位： [1]Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. [2]Department of Hepato-Pancreato-Biliary Surgery, Shandong Provincial Hospital, Shandong 250000, China. [3]Department of Hepatobiliary Surgery, First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. [4]Department of Pancreas Center, Department of General Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong 510080, China. [5]Department of Pancreatic-Hepatobiliary Surgery, The Second Affiliated Hospital, Army Medical University, PLA, Chongqing 404100, China. [6]Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, 71 Xinmin Street, Jilin 130021, China. [7]Hepatobiliary and Pancreatic Surgery Department, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China. [8]Xiangyue Hospital Affiliated to Hunan Institute of Parasitic Diseases, National Clinical Center for Schistosomiasis Treatment, Yueyang, Hunan, China. [9]Department of Hepatobiliary Surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China. [10]Department of Hepatopancreatobiliary Surgery, the Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213003, China. [11]Department of Hepato-Pancreato-Biliary Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221004, China. [12]Department of Hepatobiliary Surgery, Affiliated Hospital of North Sichuan Medical College, Sichuan 637000, China. [13]Department of Hepatobiliary and Pancreatic Surgery, Guangdong Hospital of Traditional Chinese Medicine, Guangzhou, Guangdong 510120, China. [14]Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China. [15]Department of Hepatobiliary Pancreatic Surgery, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, No.7 Wei Wu Road, Zhengzhou, Henan, 450003, China.
出处：
DOI： 10.1097/SLA.0000000000006149
ISSN：

摘要：
This study aimed to estimate whether the potential short-term advantages of laparoscopic pancreaticoduodenectomy (LPD) could allow patients to recover in a more timely manner and achieve better long-term survival than with open pancreaticoduodenectomy (OPD) in patients with pancreatic or periampullary tumors.LPD has been demonstrated to be feasible and may have several potential advantages over OPD in terms of shorter hospital stay and accelerated recovery than OPD.This noninferiority, open-label, randomized clinical trial was conducted in 14 centers in China. The initial trial included 656 eligible patients with pancreatic or periampullary tumors enrolled from May 18, 2018, to December 19, 2019. The participants were randomized preoperatively in a 1:1 ratio to undergo either LPD (n=328) or OPD (n=328). The 3-year OS, quality of life, which was assessed using the 3-level version of the EQ-5D (EQ-5D-3L), depression, and other outcomes were evaluated.Data from 656 patients (328 men [69.9%]; mean [SD] age: 56.2 [10.7] years) who underwent PD were analyzed. For malignancies, the 3-year OS rates were 59.1% and 54.3% in the LPD and OPD groups, respectively (P=0.33, hazard ratio [HR]: 1.16, 95% confidence interval [CI]: 0.86-1.56). The 3-year OS rates for others were 81.3% and 85.6% in the LPD and OPD groups, respectively (P=0.40, HR: 0.70, 95% CI: 0.30-1.63). No significant differences were observed in quality of life, depression and other outcomes between the two groups.In patients with pancreatic or periampullary tumors, LPD performed by experienced surgeons resulted in a similar 3-year OS compared with OPD.Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.

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外文
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出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 外科
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 外科
第一作者：
第一作者单位： [1]Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
通讯作者：
通讯机构： [1]Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. [*1]Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, Hubei, 430030, China.
推荐引用方式(GB/T 7714)：
Qin Tingting,Zhang Hang,Pan Shutao,et al.Effect of Laparoscopic and Open Pancreatoduodenectomy for Pancreatic or Periampullary Tumors: Three-year Follow-up of a Randomized Clinical Trial[J].Annals Of Surgery.2023,doi:10.1097/SLA.0000000000006149.
APA：
Qin Tingting,Zhang Hang,Pan Shutao,Liu Jun,Li Dewei...&Qin Renyi.(2023).Effect of Laparoscopic and Open Pancreatoduodenectomy for Pancreatic or Periampullary Tumors: Three-year Follow-up of a Randomized Clinical Trial.Annals Of Surgery,,
MLA：
Qin Tingting,et al."Effect of Laparoscopic and Open Pancreatoduodenectomy for Pancreatic or Periampullary Tumors: Three-year Follow-up of a Randomized Clinical Trial".Annals Of Surgery .(2023)

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