Platelet membrane fusion liposome loaded with type I AIE photosensitizer to induce chemoresistance cancer pyroptosis and immunogenic cell death for enhancing cancer immunotherapy
单位：[1]Department of General Surgery & Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, The First School of[2]Department of Anesthesiology, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, China[3]Department of Breast Surgery, Wuzhou Red Cross Hospital, Wuzhou, China[4]Department of Gastrointestinal Surgery & Department of Geriatrics, Shenzhen People’s Hospital The Second Clinical Medical College, Jinan University, The First深圳市康宁医院深圳市人民医院深圳医学信息中心[5]Department of Plastic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China外科学系整形美容外科华中科技大学同济医学院附属同济医院
Cancer cells often develop resistance to chemotherapy induced apoptosis, and targeting non-apoptosis-related pathways is a potential anti-drug resistant tumor strategy. Here, we designed a platelet membrane fusion lipo-some nanovesicle system (named TFL) loaded with type I aggregation induced-emission (AIE) photosensitizer (TBP-2), which is used to promote the pyroptosis and immunogenic cell death (ICD) of chemoresistance breast cancer cells. Because of the highly expressed P-selectin protein in platelets, TFL can target the highly expressed CD44 receptor in chemoresistance breast cancer cells and deliver TBP-2 molecules to these cells. Under the irradiation of external light sources, TBP-2 achieves type-I photodynamic therapy (PDT), generating a large number of hydroxyl free radicals, inducing pyroptosis and ICD of chemoresistance cancer cells, promoting DC cell maturation and T cell infiltration. In vivo animal experiments have shown that the TFL system can promote T cell immunity, slow down distal chemoresistance tumor growth, achieve immune memory effect, and inhibit chemoresistance tumor rechallenge. Compared with high-dose chemotherapy, TFL + L has better immune stimulation and therapeutic effect on drug-resistant breast cancer. This system may become an adjuvant therapy for clinical chemotherapy in the future, further enhancing the immune response and therapy effect of drug-resistant tumors.
基金：
Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University [2021J008]; Science and Technology Projects in Guangzhou [2023A04J2370, 202102020026]; GuangDong Basic and Applied Basic Research Foundation [2021A1515010022, 2023A1515011787]; Launch Funding for Talent Introduction of Southern Medical University [R10101041]
第一作者单位：[1]Department of General Surgery & Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, The First School of
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推荐引用方式(GB/T 7714)：
Chen Hao,Luo Xi,Huang Qinghua,et al.Platelet membrane fusion liposome loaded with type I AIE photosensitizer to induce chemoresistance cancer pyroptosis and immunogenic cell death for enhancing cancer immunotherapy[J].CHEMICAL ENGINEERING JOURNAL.2023,476:doi:10.1016/j.cej.2023.146276.
APA：
Chen, Hao,Luo, Xi,Huang, Qinghua,Liu, Zeming,Lyu, Meng...&Zhu, Daoming.(2023).Platelet membrane fusion liposome loaded with type I AIE photosensitizer to induce chemoresistance cancer pyroptosis and immunogenic cell death for enhancing cancer immunotherapy.CHEMICAL ENGINEERING JOURNAL,476,
MLA：
Chen, Hao,et al."Platelet membrane fusion liposome loaded with type I AIE photosensitizer to induce chemoresistance cancer pyroptosis and immunogenic cell death for enhancing cancer immunotherapy".CHEMICAL ENGINEERING JOURNAL 476.(2023)
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