Background: Sarcopenia is an aging-related degeneration of muscle mass and strength. Small-molecule inhibitor SW033291 has been shown to attenuate muscle atrophy. Targeted nanodrug-delivery systems can improve the efficacy of small-molecule inhibitors. Methods: The skeletal muscle cell-targeted nanoparticle was called AP@SW033291, which consisted of SW033291, modular peptide ASSLNIAGGRRRRRG and PEG-DSPE. Nanoparticles were featured with particle size, fluorescence emission spectra and targeting ability. We also investigated their effects on muscle mass and function. Results: The size of AP@SW033291 was 125.7 nm and it demonstrated targeting effects on skeletal muscle; thus, it could improve muscle mass and muscle function. Conclusion: Nanoparticle AP@SW033291 could become a potential strategy to strengthen the treatment effects of small-molecule inhibitors in sarcopenia.
基金：
National Key Research and Development Program of China [2022YFC2009700]; National Natural Science Foundation of China [82201751]; Natural Science Foundation of Jiangsu Province [BK20190351]; Jiangsu Province Capability Improvement Project through Science, Technology and Education, Jiangsu Provincial Medical Key Discipline Cultivation Unit [JSDW202202]; Jiangsu Province Key Research and Development Program [BE2020718]; Jiangsu Province Capability Improvement Project through Science, Technology and Education [ZDXYS202210]
第一作者单位：[1]Southeast Univ, Zhongda Hosp, Sch Med, Dept Rehabil, Nanjing, Jiangsu, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Jinyu,He Yikang,Wang Baoyue,et al.Muscle-targeted nanoparticles strengthen the effects of small-molecule inhibitors in ameliorating sarcopenia[J].NANOMEDICINE.2023,18(23):1635-1649.doi:10.2217/nnm-2023-0201.
APA：
Wang, Jinyu,He, Yikang,Wang, Baoyue,Yin, Ruian,Chen, Biao&Wang, Hongxing.(2023).Muscle-targeted nanoparticles strengthen the effects of small-molecule inhibitors in ameliorating sarcopenia.NANOMEDICINE,18,(23)
MLA：
Wang, Jinyu,et al."Muscle-targeted nanoparticles strengthen the effects of small-molecule inhibitors in ameliorating sarcopenia".NANOMEDICINE 18..23(2023):1635-1649
