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Lysosomal control of dendritic cell function

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收录情况： ◇ SCIE

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单位： [1]Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [2]Department of Respiratory and Critical Care Medicine, The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China. [3]Department of Gerontology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan, China.

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关键词： Dendritic cell (DC) Lysosome Immune response DC based immunotherapy

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Lysosomal compartments undergo extensive remodeling during dendritic cell (DC) activation to meet the dynamic functional requirements of DCs. Instead of being regarded as stationary and digestive organelles, recent studies have increasingly appreciated the versatile roles of lysosomes in regulating key aspects of DC biology. Lysosomes actively control DC motility by linking calcium efflux to the actomyosin contraction, while enhanced DC lysosomal membrane permeability (LMP) contributes to the inflammasome activation. Besides, lysosomes provide a platform for the transduction of innate immune signaling and the intricate host-pathogen interplay. Lysosomes and lysosome-associated structures are also critically engaged in antigen presentation and cross-presentation processes, which are pivotal for the induction of antigen specific adaptive immune response. Through the current review, we emphasize that lysosome targeting strategies serve as vital DC based immunotherapies in fighting against tumor, infectious diseases and autoinflammatory disorders.© The Author(s) 2023. Published by Oxford University Press on behalf of Society for Leukocyte Biology.

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出版当年[2022]版：

大类 | 3 区医学

小类 | 3 区细胞生物学 3 区免疫学 3 区血液学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区细胞生物学 4 区血液学 4 区免疫学

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出版当年[2021]版：

Q2 CELL BIOLOGY Q2 HEMATOLOGY Q2 IMMUNOLOGY

最新[2023]版：

Q2 HEMATOLOGY Q2 IMMUNOLOGY Q3 CELL BIOLOGY

影响因子： 3.6 最新[2023版] 5.2 最新五年平均 6.011 出版当年[2021版] 5.854 出版当年五年平均 4.962 出版前一年[2020版] 5.5 出版后一年[2022版]

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第一作者单位： [1]Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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