单位：[1]Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.口腔科华中科技大学同济医学院附属同济医院[2]School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.[3]Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430022, China.
Oral squamous cell carcinoma (OSCC) is a prevalent form of malignant tumor, characterized by a persistently high incidence and mortality rate. The extracellular matrix (ECM) plays a crucial role in the initiation, progression, and diverse biological behaviors of OSCC, facilitated by mechanisms such as providing structural support, promoting cell migration and invasion, regulating cell morphology, and modulating signal transduction. This study investigated the involvement of ECM-related genes, particularly THBS1, in the prognosis and cellular behavior of OSCC. The analysis of ECM-related gene data from OSCC samples identified 165 differentially expressed genes forming two clusters with distinct prognostic outcomes. Seventeen ECM-related genes showed a significant correlation with survival. Experimental methods were employed to demonstrate the impact of THBS1 on proliferation, migration, invasion, and ECM degradation in OSCC cells. A risk-prediction model utilizing four differentially prognostic genes demonstrated significant predictive value in overall survival. THBS1 exhibited enrichment of the PI3K/AKT pathway, indicating its potential role in modulating OSCC. In conclusion, this study observed and verified that ECM-related genes, particularly THBS1, have the potential to influence the prognosis, biological behavior, and immunotherapy of OSCC. These findings hold significant implications for enhancing survival outcomes and providing guidance for precise treatment of OSCC.
基金：
Natural Science Foundation of Hubei Province (2021CFB367,
to S.G.) and the National Natural Science Foundation of China (Grant no. 81771121, to S.G.).
第一作者单位：[1]Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.[2]School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.[3]Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430022, China.
推荐引用方式(GB/T 7714)：
Wen Zhihao,Zhang Yuxiao,Wang Xiangyao,et al.THBS1-Mediated Degradation of Collagen via the PI3K/AKT Pathway Facilitates the Metastasis and Poor Prognosis of OSCC[J].INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2023,24(17):doi:10.3390/ijms241713312.
APA：
Wen Zhihao,Zhang Yuxiao,Wang Xiangyao,Wu Yaxin,Mao Jing...&Gong Shiqiang.(2023).THBS1-Mediated Degradation of Collagen via the PI3K/AKT Pathway Facilitates the Metastasis and Poor Prognosis of OSCC.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24,(17)
MLA：
Wen Zhihao,et al."THBS1-Mediated Degradation of Collagen via the PI3K/AKT Pathway Facilitates the Metastasis and Poor Prognosis of OSCC".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24..17(2023)
生物学