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DAB2IP suppresses invadopodia formation through destabilizing ALK by interacting with USP10 in breast cancer

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收录情况： ◇ SCIE

作者：
Huang Qingwen[1,2] * ; Zhang Rui[1,2] * ; Xia Yun[3] * ; Shen Jie[1,2] ; Dong Hongliang[1,2] ; Li Xiaolan[1] ; Tao Deding[2] ; Xie Daxing[1,2] ; Liu Liang[1,2] ;
单位： [1]Molecular Medicine Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,P.R. China. [2]Department of GI Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,P.R. China. [3]Department of Breast and Thyroid Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,P.R. China.
出处：
DOI： 10.1016/j.isci.2023.107606
ISSN：

摘要：
Invadopodia, being actin-rich membrane protrusions, play a vital role in tumor cell invasion and metastasis. Our previous studies have revealed some functions of the DOC-2/DAB2 interacting protein (DAB2IP) as a tumor suppressor. Nevertheless, the specific role and mechanism of DAB2IP in invadopodia formation remain unclear. Here, we find that DAB2IP effectively suppresses invadopodia formation and metastasis in breast cancer, both in vitro and in vivo. Additionally, DAB2IP could downregulate anaplastic lymphoma kinase (ALK), resulting in the inhibition of tyrosine phosphorylation of Cortactin and the prevention of invadopodia formation. DAB2IP competitively antagonizes the interaction between the deubiquitinating enzyme Ubiquitin-specific peptidase 10 (USP10) and ALK, leading to a decrease in the abundance of ALK protein. In summary, DAB2IP impairs the stability of ALK through USP10-dependent deubiquitination, suppressing Cortactin phosphorylation, thereby inhibiting invadopodia formation and metastasis of breast cancer cells. Furthermore, this study suggests a potential therapeutic strategy for breast cancer treatment.© 2023 The Author(s).

基金：
This work was supported by the National Natural Science Foundation of China (grant numbers:81702897, 81773053, 81302309, and 82273061).
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外文
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出版当年[2022]版：
大类 | 2 区 综合性期刊
小类 | 2 区 综合性期刊
最新[2025]版：
大类 | 2 区 综合性期刊
小类 | 2 区 综合性期刊
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出版当年[2021]版：
Q1 MULTIDISCIPLINARY SCIENCES
最新[2023]版：
Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者单位： [1]Molecular Medicine Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,P.R. China. [2]Department of GI Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,P.R. China.
共同第一作者：
通讯作者：
通讯机构： [1]Molecular Medicine Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,P.R. China. [2]Department of GI Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,P.R. China.
推荐引用方式(GB/T 7714)：
Huang Qingwen,Zhang Rui,Xia Yun,et al.DAB2IP suppresses invadopodia formation through destabilizing ALK by interacting with USP10 in breast cancer[J].ISCIENCE.2023,26(9):doi:10.1016/j.isci.2023.107606.
APA：
Huang Qingwen,Zhang Rui,Xia Yun,Shen Jie,Dong Hongliang...&Liu Liang.(2023).DAB2IP suppresses invadopodia formation through destabilizing ALK by interacting with USP10 in breast cancer.ISCIENCE,26,(9)
MLA：
Huang Qingwen,et al."DAB2IP suppresses invadopodia formation through destabilizing ALK by interacting with USP10 in breast cancer".ISCIENCE 26..9(2023)

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