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Ginsenoside Rd attenuates myocardial ischemia injury through improving mitochondrial biogenesis via WNT5A/Ca2+ pathways

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Pubmed体系：

收录情况： ◇ SCIE

作者：
Cui Zekun[1] * ; Gu Lifei[4] ; Liu Tao[1] ; Liu Yining[1] ; Yu Boyang[1] ; Kou Junping[1] ; Li Fang[1] ; Yang Kun[2,3] ;
单位： [1]Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Research Center for Traceability and Standardization of TCMs, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, 211198, China [2]Department of Endocrinology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China [3]Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China [4]NMPA Key Laboratory for Quality Research and Evaluation of Traditional Chinese Medicine, Shenzhen Institute for Drug Control, Shenzhen, China
出处：
DOI： 10.1016/j.ejphar.2023.176044
ISSN：

关键词： Ginsenoside Rd Myocardial ischemia mitochondrial biogenesis WNT5A

摘要：
Ginsenoside Rd, one of the main active components in ginseng, exerts various biological activities. However, its effectiveness on myocardial ischemia injury and its potential mechanism need further clarification. The model of isoproterenol (ISO)-induced myocardial ischemia injury (MI) mice and cobalt chloride (CoCl2)-induced cardiomyocytes injury were performed. Ginsenoside Rd significantly alleviated MI injury, as evidenced by ameliorated cardiac pathological features and improved cardiac function. Simultaneously, ginsenoside Rd notably mitigated CoCl2-induced cell injury, decreased the lactate dehydrogenase (LDH) release and reactive oxygen species (ROS) generation in vitro. Additionally, ginsenoside Rd increased nicotinamide adenine dinucleotide (NADH) and mitochondrial membrane potential (MMP). Moreover, we found that ginsenoside Rd could increase the mitochondrial DNA (mtDNA) and promote the expression of Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC1α), nuclear factor erythroid 2 related factor-1 (NRF1), nuclear factor erythroid 2 related factor-2 (NRF2) and activating mitochondrial transcription factor A (TFAM), which suggested that ginsenoside Rd might accelerate mitochondrial biogenesis function to ameliorate MI injury. Importantly, ginsenoside Rd treatment significantly inhibited the WNT5A/calcium (Ca2+) signaling pathway, decreased the expression of WNT5A, Frizzled2, phosphorylated calmodulin kinase II/calmodulin kinase II (p-CaMKII/CaMKII) and the calcium overload. Meanwhile, WNT5A siRNA was further conducted to elucidate the effect of ginsenoside Rd on CoCl2-induced cardiomyocyte injury. And we found that WNT5A siRNA partially weakened the protective effects of ginsenoside Rd on mitochondrial function and mitochondrial biogenesis, suggesting that ginsenoside Rd might suppress myocardial ischemia injury through WNT5A. Overall, this study demonstrated that ginsenoside Rd could alleviate myocardial ischemia injury through improving mitochondrial biogenesis via WNT5A/Ca2+ pathways, which provided a rationale for future clinical applications and potential drugs for the treatment of cardiovascular diseases.Copyright © 2023 Elsevier B.V. All rights reserved.

基金：
This research was funded by the National Natural Science Foundation of China (No. 82274231, 81973506), State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University), (CMEMR2023-B12), the Fundamental Research Funds for the Central Universities (2632023TD06), Shenzhen Science and Technology Program (No. JCYJ20220531091217040), the Natural Science Foundation for Young Scientists of Shanxi Province (No. 20210302124571), Young Talent Support Project of Jiangsu Association for Science and Technology (TJ-2022-025) and Qinglan Project of Jiangsu Province.
语种：
外文
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WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 医学
小类 | 2 区 药学
最新[2025]版：
大类 | 3 区 医学
小类 | 2 区 药学
JCR分区：
出版当年[2021]版：
Q2 PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者单位： [1]Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Research Center for Traceability and Standardization of TCMs, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, 211198, China
通讯作者：
通讯机构： [2]Department of Endocrinology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China [3]Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
推荐引用方式(GB/T 7714)：
Cui Zekun,Gu Lifei,Liu Tao,et al.Ginsenoside Rd attenuates myocardial ischemia injury through improving mitochondrial biogenesis via WNT5A/Ca2+ pathways[J].EUROPEAN JOURNAL OF PHARMACOLOGY.2023,957:doi:10.1016/j.ejphar.2023.176044.
APA：
Cui Zekun,Gu Lifei,Liu Tao,Liu Yining,Yu Boyang...&Yang Kun.(2023).Ginsenoside Rd attenuates myocardial ischemia injury through improving mitochondrial biogenesis via WNT5A/Ca2+ pathways.EUROPEAN JOURNAL OF PHARMACOLOGY,957,
MLA：
Cui Zekun,et al."Ginsenoside Rd attenuates myocardial ischemia injury through improving mitochondrial biogenesis via WNT5A/Ca2+ pathways".EUROPEAN JOURNAL OF PHARMACOLOGY 957.(2023)

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