Bone adhesive is a promising material for the treatment of bone fractures, which is helpful for the fast and effective reduction and fixation of broken bones. However, the existing adhesives bond weakly to bone tissues, and are non-absorbable, or hard to cure under wet conditions. Herein, inspired by the cement-based adhesive used in the industry field, we report a bioactive calcium and magnesium phosphate bone adhesive (MPBA) with the properties of facile preparation, robust adhesion, and bioactive. MPBA is equipped with similar strength to cancellous bones and shows reliable bonding performance for various interfaces, such as Ti 6 Al 4 V, Al 2 O 3 , and poly(ether-ether-ketone). MPBA achieves excellent bonding ability for the above interfaces with the bonding strengths of 2.28 & PLUSMN;0.47, 2.32 & PLUSMN;0.15, and 1.44 & PLUSMN;0.38 MPa, respectively. Besides, it also shows reliable fixation ability for bovine bone surfaces. The bonding behavior to materials and bones suggests that MPBA could be used for both fracture treatment and implant fixation. Meanwhile, MPBA possesses good biological activity, which could promote the vascularization process and osteogenic differentiation. Finally, in vivo experiments confirmed MPBA can effectively restore bone strength and promote bone regeneration. & COPY; 2023 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.