Dose-Response Relationship between Gestational Weight Gain and Neonatal Birthweight in Chinese Women with Excess Weight/Obesity and Gestational Diabetes Mellitus
单位：[1]Nursing Department,Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology,1095 Jiefang Avenue,Wuhan 430030,China.华中科技大学同济医学院附属同济医院护理部[2]School of Nursing, Tongji Medical College of Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China.[3]Department of Gynaecology and Obstetrics, Chongqing Health Center for Women and Children (Women and Children's Hospital of Chongqing Medical University), 120 Longshan Road, Chongqing 401147, China.
Total gestational weight gain (GWG) is identified as a strong and potentially controllable predictor of long-term health outcomes in women with gestational diabetes mellitus (GDM) and infants. When the total GWG of women with excess weight/obesity and GDM does not exceed the Institute of Medicine (IOM) suggested range, neonatal birthweight outcomes may be favorable, but the evidence is limited. Therefore, the objective of this study was to evaluate the dose-response relationship between increased total GWG and the risk of neonatal birthweight in Chinese women with excess weight/obesity and GDM. This study obtained electronic medical records (EMR) from the hospital information system (HIS) of the Chongqing Health Center for Women and Children between July 2017, and June 2020. A retrospective study analyzed the effect of the total GWG of women with excess weight/obesity and GDM on neonatal birthweight. The dose-response relationship between total GWG and neonatal birthweight was studied using a generalized linear model and embedded restricted cubic splines (RCS). The average age of all women with GDM was 31.99 ± 4.47 years, and 27.61% were advanced maternal age (≥35 years). The total GWG among women with excess weight and obesity and GDM greater than the IOM recommendations were found in 42.96% and 58.62% of cases, respectively. Total GWG in women with excess weight and excessing the IOM recommended range is a risk factor for large gestational age (LGA) [adjusted odds ratio (aOR) 0.1.47, 1.08-2.01] and macrosomia (aOR 1.55, 1.04-2.31). In the obesity above group, excessive weight gain increased the risk of LGA (aOR 2.92, 1.33-6.41) and macrosomia (aOR 2.83, 1.03-7.72). We used an RCS to examine pregnant women with excess weight and GDM and discovered a linear dose-response relationship between total GWG and LGA/macrosomia. In women with excess weight and obesity, increases in total GWG above the lowest end of the IOM recommendations range (7 kg and 5 kg) were associated with an increased risk of LGA and macrosomia. Therefore, research is urgently needed to support maternal and newborn health to provide recommendations for the ideal weight increase in women with excess weight/obesity and GDM.
基金：
This research was funded by the Research financed by the Research Major Project for Tongji
Hospital of Tongji Medical College of Huazhong University of Science and Technology (Number
2022C06) and Wuhan Nursing Association in China (Number WHHL2s2201).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|4 区医学
小类|4 区卫生政策与服务4 区卫生保健与服务
最新[2025]版：
大类|4 区医学
小类|4 区卫生保健与服务4 区卫生政策与服务
JCR分区：
出版当年[2021]版：
Q2HEALTH CARE SCIENCES & SERVICESQ2HEALTH POLICY & SERVICES
最新[2023]版：
Q2HEALTH CARE SCIENCES & SERVICESQ2HEALTH POLICY & SERVICES
第一作者单位：[1]Nursing Department,Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology,1095 Jiefang Avenue,Wuhan 430030,China.[2]School of Nursing, Tongji Medical College of Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China.
通讯作者：
推荐引用方式(GB/T 7714)：
He Jing,Hu Kaili,Wang Binghua,et al.Dose-Response Relationship between Gestational Weight Gain and Neonatal Birthweight in Chinese Women with Excess Weight/Obesity and Gestational Diabetes Mellitus[J].HEALTHCARE.2023,11(16):doi:10.3390/healthcare11162358.
APA：
He Jing,Hu Kaili,Wang Binghua,Chen Zhen&Wang Hui.(2023).Dose-Response Relationship between Gestational Weight Gain and Neonatal Birthweight in Chinese Women with Excess Weight/Obesity and Gestational Diabetes Mellitus.HEALTHCARE,11,(16)
MLA：
He Jing,et al."Dose-Response Relationship between Gestational Weight Gain and Neonatal Birthweight in Chinese Women with Excess Weight/Obesity and Gestational Diabetes Mellitus".HEALTHCARE 11..16(2023)
