单位：[1]School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.[2]College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China.[3]College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.[4]Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430070,China.外科学系华中科技大学同济医学院附属同济医院泌尿外科[5]College of Informatics, Huazhong Agricultural University, Wuhan 430070, China.[6]Department of Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430079, China.
Metabolic dysregulation has been reported involving in the clinical outcomes of multiple cancers. However, systematical identification of the impact of metabolic pathways on cancer prognosis is still lacking. Here, we performed a pan-cancer analysis of popular metabolic checkpoint genes and pathways with cancer prognosis by integrating information of clinical survival with gene expression and pathway activity in multiple cancer patients. By discarding the effects of age and sex, we revealed extensive and significant associations between the survival of cancer patients and the expression of metabolic checkpoint genes, as well as the activities of three primary metabolic pathways: amino acid metabolism, carbohydrate metabolism, lipid metabolism, and eight nonprimary metabolic pathways. Among multiple cancers, we found the survival of kidney renal clear cell carcinoma and low-grade glioma exhibit high metabolic dependence. Our work systematically assesses the impact of metabolic checkpoint genes and pathways on cancer prognosis, providing clues for further study of cancer diagnosis and therapy.
基金：
This research was funded by National Natural Science Foundation of China (82170170) and
the Fundamental Research Funds for the Central Universities (2662022SYYJ001)
第一作者单位：[1]School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
共同第一作者：
通讯作者：
通讯机构：[1]School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.[2]College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China.
推荐引用方式(GB/T 7714)：
Chen Wenbo,Chen Xin,Zhao Zhenyu,et al.Pan-Cancer Identification of Prognostic-Associated Metabolic Pathways[J].BIOLOGY-BASEL.2023,12(8):doi:10.3390/biology12081129.
