单位：[1]Capstone College of Nursing, The University of Alabama, Tuscaloosa, AL, USA.[2]Department of Sociology, University of Alabama at Birmingham, Birmingham, AL, USA.[3]School of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.[4]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.华中科技大学同济医学院附属同济医院[5]Department of Clinical and Diagnostic Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.[6]Department of Anesthesiology, Washington University Pain Center, Washington University, St. Louis, MO, USA.
Mild to moderate forms of neurocognitive impairment persist among people living with HIV (PLWH), despite being virally suppressed on antiretroviral therapy. PLWH are disproportionally impacted by physiological and psychosocial comorbidities compared to those without HIV. As adults live longer with HIV, the neurocognitive burden of physiological and psychosocial stressors can impair everyday functioning and may contribute to the development of neurodegenerative diseases such as Alzheimer's disease. This article outlines neurocognitive consequences of everyday stressors in PLWH. While some lifestyle factors can exacerbate inflammatory processes and promote negative neurocognitive health, novel interventions including the use of cannabinoids may be neuroprotective for aging PLWH who are at risk for elevated levels of inflammation from comorbidities. Studies of integrated neurocognitive rehabilitation strategies targeting lifestyle factors are promising for improving neurocognitive health, and may over time, reduce the risk of Alzheimer's disease in PLWH.
基金：
Dr. Miller is supported by a Robert Wood John- 921
son Foundation Health Equity Scholars for Action 922
program grant (80065). Dr. Fazeli is supported by 923
an NIH/National Institute of Mental Health grant 924
(1R01MH131177), an NIH/National Institute on 925
Aging grant (R21AG076377), and an Alzheimer’s 926
Association and National Academy of Neuropsy- 927
chology (ALZ-NAN-22-926241). Dr. Goodin is 928
supported by an NIH/National Heart Lung and 929
Blood Institute grant (R01HL147603). Dr. Cody 930
is supported by a research supplement to pro- 931
mote diversity in health-related research under this 932
award. Dr. Vance is supported by an NIH/National 933
Institute of Mental Health grant (1R01MH106366- 934
01A1) and an NIH/National Institute on Aging grant 935
(R21AG077957)
第一作者单位：[1]Capstone College of Nursing, The University of Alabama, Tuscaloosa, AL, USA.[*1]AGNP-C, Associate Professor, 650 University Blvd, Tuscaloosa, AL 35274, USA.
通讯作者：
通讯机构：[1]Capstone College of Nursing, The University of Alabama, Tuscaloosa, AL, USA.[*1]AGNP-C, Associate Professor, 650 University Blvd, Tuscaloosa, AL 35274, USA.
推荐引用方式(GB/T 7714)：
Cody Shameka L,Miller Gabe H,Fazeli Pariya L,et al.Preventing Neurocognitive Decline in Adults Aging with HIV: Implications for Practice and Research[J].JOURNAL OF ALZHEIMERS DISEASE.2023,95(3):753-768.doi:10.3233/JAD-230203.
APA：
Cody Shameka L,Miller Gabe H,Fazeli Pariya L,Wang Ge,Li Wei...&Vance David E.(2023).Preventing Neurocognitive Decline in Adults Aging with HIV: Implications for Practice and Research.JOURNAL OF ALZHEIMERS DISEASE,95,(3)
MLA：
Cody Shameka L,et al."Preventing Neurocognitive Decline in Adults Aging with HIV: Implications for Practice and Research".JOURNAL OF ALZHEIMERS DISEASE 95..3(2023):753-768
