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A life-threatening bleeding prediction model for immune thrombocytopenia based on personalized machine learning: a nationwide prospective cohort study

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收录情况： ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C ◇ 卓越：领军期刊

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单位： [1]Peking University People's Hospital, Peking University Institute of Hematology, Beijing 100044, China; Collaborative Innovation Center of Hematology, Peking University, Beijing 100044, China; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing 100044, China; National Clinical Research Center for Hematologic Disease, Beijing 100044, China. [2]Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250014, China. [3]Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China. [4]Department of Hematology, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi 832002, China. [5]Department of Hematology, Qinghai Provincial People's Hospital, Xining 810007, China. [6]Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Henan Institute of Hematology, Zhengzhou 450008, China. [7]Department of Hematology, Beijing Hospital, Beijing 100044, China. [8]Department of Hematology, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou 310006, China. [9]Department of Hematology, Senior Department of Hematology, the Fifth Medical Center of PLA General Hospital, Beijing 100044, China. [10]Department of Hematology, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China. [11]Department of Hematology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China. [12]Department of Hematology, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province People Hospital), Nanjing 210029, China. [13]Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai 200032, China. [14]Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008, China. [15]Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing 100044, China. [16]Institute of Hematology, the First Affiliated Hospital, Zhejiang University, Hangzhou 310058, China. [17]Department of Hematology, Beijing Tongren Hospital, Beijing 100005, China. [18]Department of Hematology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. [19]Medical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing 400037, China. [20]Department of Hematology, First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China. [21]Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250014, China. [22]Department of Hematology, Tianjin Medical University General Hospital, Tianjin 300052, China. [23]Institute of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China. [24]Department of Hematology, Fujian Institute of Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, China. [25]Department of Hematology, the First People's Hospital of Yunnan Province, Kunming 650032, China. [26]Department of Hematology, Shanxi Tumor Hospital Affiliated to Shanxi Medical University, Taiyuan 030001, China. [27]Department of Hematology, Shanxi Bethune Hospital of Shanxi Medical University, Taiyuan 030001, China. [28]Department of Hematology, The Affiliated Hospital of Northwest Hospital, Xi'an No.3 Hospital, Xi'an 710054, China. [29]Department of Hematology, Chinese PLA General Hospital & PLA Medical School, Beijing 100044, China. [30]Department of Hematology, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou 570311, China. [31]Department of Hematology, Peking University Shenzhen Hospital, Shenzhen 518036, China. [32]Center of Hematologic Diseases, The First Affiliated Hospital of Xinjiang Medical University, Urumchi 830054, China. [33]Department of Hematology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650500, China. [34]Department of Hematology, Peking University First Hospital, Beijing 100034, China. [35]Department of Hematology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, China. [36]Department of Hematology, People's Hospital of Tibet Autonomous Region, Lhasa 850000, China. [37]Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China. [38]Department of Hematology, The 940th Hospital of Joint Logistics Support Force of Chinese PLA, Lanzhou 730050, China. [39]Institute of Hematology, Harbin the First Hospital, Harbin 150001, China. [40]Department of Hematology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China. [41]Department of Hematology, Inner Mongolia People's Hospital, Hohhot 010017, China. [42]Department of Hematology, The First Bethune Hospital of Jilin University, Changchun 130021, China. [43]State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China. Electronic address: zhanglei1@ihcams.ac.cn. [44]Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250014, China. Electronic address: houming2019@tom.com. [45]Peking University People's Hospital, Peking University Institute of Hematology, Beijing 100044, China; Collaborative Innovation Center of Hematology, Peking University, Beijing 100044, China; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing 100044, China; National Clinical Research Center for Hematologic Disease, Beijing 100044, China. Electronic address: xjhrm@medmail.com.cn. [46]Peking University People's Hospital, Peking University Institute of Hematology, Beijing 100044, China; Collaborative Innovation Center of Hematology, Peking University, Beijing 100044, China; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing 100044, China; National Clinical Research Center for Hematologic Disease, Beijing 100044, China. Electronic address: zhangxh@bjmu.edu.cn.

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Rare but critical bleeding events in primary immune thrombocytopenia (ITP) present life-threatening complications in patients with ITP, which severely affect their prognosis, quality of life, and treatment decisions. Although several studies have investigated the risk factors related to critical bleeding in ITP, large sample size data, consistent definitions, large-scale multicenter findings, and prediction models for critical bleeding events in patients with ITP are unavailable. For the first time, in this study, we applied the newly proposed critical ITP bleeding criteria by the International Society on Thrombosis and Hemostasis for large sample size data and developed the first machine learning (ML)-based online application for predict critical ITP bleeding. In this research, we developed and externally tested an ML-based model for determining the risk of critical bleeding events in patients with ITP using large multicenter data across China. Retrospective data from 8 medical centers across the country were obtained for model development and prospectively tested in 39 medical centers across the country over a year. This system exhibited good predictive capabilities for training, validation, and test datasets. This convenient web-based tool based on a novel algorithm can rapidly identify the bleeding risk profile of patients with ITP and facilitate clinical decision-making and reduce the occurrence of adversities.Copyright © 2023 Science China Press. Published by Elsevier B.V. All rights reserved.

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出版当年[2022]版：

大类 | 1 区

综合性期刊

小类 | 1 区综合性期刊

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大类 | 1 区

综合性期刊

小类 | 1 区综合性期刊

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出版当年[2021]版：

Q1 MULTIDISCIPLINARY SCIENCES

最新[2023]版：

Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 18.8 最新[2023版] 15.9 最新五年平均 20.577 出版当年[2021版] 12.624 出版当年五年平均 11.78 出版前一年[2020版] 18.9 出版后一年[2022版]

第一作者：

第一作者单位： [1]Peking University People's Hospital, Peking University Institute of Hematology, Beijing 100044, China; Collaborative Innovation Center of Hematology, Peking University, Beijing 100044, China; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing 100044, China; National Clinical Research Center for Hematologic Disease, Beijing 100044, China.

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