Six griseofulvin analogues named penigriseofulvins A -F (1-6), including three undescribed compounds and three undescribed natural products, were isolated from the fungus Penicillium griseofulvum. Their structures and absolute configurations were determined by NMR spectroscopic analyses, HRESIMS, and X-ray diffraction experiments. All compounds were evaluated for their anti-inflammatory activity, of which compounds 1 and 4 showed potential anti-inflammatory effects in RAW264.7 macrophages and ulcerative colitis mice.
基金：
National Key Research and Development Program of China [2021YFA0910500]; National Natural Science Foundation of China [U22A20380, 82173706]; Inno-vative Research Groups of the National Natural Science Foundation of China [81721005]; Science and Technology Major Project of Hubei Province [2021ACA012]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
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推荐引用方式(GB/T 7714)：
Liang Yu,Zhang Biqiong,Li Dongyan,et al.Griseofulvin analogues from the fungus Penicillium griseofulvum and their anti-inflammatory activity[J].BIOORGANIC CHEMISTRY.2023,139:doi:10.1016/j.bioorg.2023.106736.
APA：
Liang, Yu,Zhang, Biqiong,Li, Dongyan,Chen, Xuanni,Wang, Qiwei...&Zhang, Yonghui.(2023).Griseofulvin analogues from the fungus Penicillium griseofulvum and their anti-inflammatory activity.BIOORGANIC CHEMISTRY,139,
MLA：
Liang, Yu,et al."Griseofulvin analogues from the fungus Penicillium griseofulvum and their anti-inflammatory activity".BIOORGANIC CHEMISTRY 139.(2023)
化学