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LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Li Dan-Pei[1,2] * ; Huang Li[1,2] * ; Kan Ran-Ran[1,2] ; Meng Xiao-Yu[1,2] ; Wang Shu-Yun[1,2] ; Zou Hua-Jie[1,2] ; Guo Ya-Ming[1,2] ; Luo Pei-Qiong[1,2] ; Pan Li-Meng[1,2] ; Xiang Yu-Xi[1,2] ; Mao Bei-Bei[1,2] ; Xie Yu-Yu[1,2] ; Wang Zhi-Han[1,2] ; Yang Min[1,2] ; He Rui[1,2] ; Yang Yan[1,2] ; Liu Zhe-Long[1,2] ; Xie Jun-Hui[1,2] ; Ma De-Lin[1,2] ; Zhang Ben-Ping[1,2] ; Shao Shi-Ying[1,2] ; Chen Xi[1,2] ; Xu Si-Miao[1,2] ; He Wen-Tao[1,2] ; Li Wen-Jun[3] ; Chen Yong[1,2] ; Yu Xue-Feng[1,2] ;
单位： [1]Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [2]Branch of National Clinical Research Center for Metabolic Diseases, Hubei, China. [3]Computer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
出处：
DOI： 10.1038/s41467-023-40183-3
ISSN：

摘要：
Inhibition of immunocyte infiltration and activation has been suggested to effectively ameliorate nonalcoholic steatohepatitis (NASH). Paired immunoglobulin-like receptor B (PirB) and its human ortholog receptor, leukocyte immunoglobulin-like receptor B (LILRB2), are immune-inhibitory receptors. However, their role in NASH pathogenesis is still unclear. Here, we demonstrate that PirB/LILRB2 regulates the migration of macrophages during NASH by binding with its ligand angiopoietin-like protein 8 (ANGPTL8). Hepatocyte-specific ANGPTL8 knockout reduces MDM infiltration and resolves lipid accumulation and fibrosis progression in the livers of NASH mice. In addition, PirB-/- bone marrow (BM) chimeras abrogate ANGPTL8-induced MDM migration to the liver. And yet, PirB ectodomain protein could ameliorate NASH by sequestering ANGPTL8. Furthermore, LILRB2-ANGPTL8 binding-promoted MDM migration and inflammatory activation are also observed in human peripheral blood monocytes. Taken together, our findings reveal the role of PirB/LILRB2 in NASH pathogenesis and identify PirB/LILRB2-ANGPTL8 signaling as a potential target for the management or treatment of NASH.© 2023. The Author(s).

基金：
National Natural Science Foundation of China (82270880, 81974109, and 81570740 to X.Y.), the National Key R&D Program of China (2016YFC0901203 to X.Y.) and the National Natural Science Foundation of China (82070859 to Y.C. and L.H., 82270910 to Y.C. and D.L.)
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外文
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出版当年[2022]版：
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
最新[2025]版：
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
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出版当年[2021]版：
Q1 MULTIDISCIPLINARY SCIENCES
最新[2023]版：
Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者单位： [1]Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [2]Branch of National Clinical Research Center for Metabolic Diseases, Hubei, China.
共同第一作者：
通讯作者：
通讯机构： [1]Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [2]Branch of National Clinical Research Center for Metabolic Diseases, Hubei, China.
推荐引用方式(GB/T 7714)：
Li Dan-Pei,Huang Li,Kan Ran-Ran,et al.LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis[J].NATURE COMMUNICATIONS.2023,14(1):4436.doi:10.1038/s41467-023-40183-3.
APA：
Li Dan-Pei,Huang Li,Kan Ran-Ran,Meng Xiao-Yu,Wang Shu-Yun...&Yu Xue-Feng.(2023).LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis.NATURE COMMUNICATIONS,14,(1)
MLA：
Li Dan-Pei,et al."LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis".NATURE COMMUNICATIONS 14..1(2023):4436

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