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The role of gut microbiota in diabetic peripheral neuropathy rats with cognitive dysfunction

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单位： [1]Department of Anesthesiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. [2]School of Human and Social Sciences, University of West London, London, United Kingdom. [3]Department of Anesthesiology,Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health,Wuhan Clinical Research Center for Geriatric Anesthesia,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.

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关键词： diabetic peripheral neuropathy cognitive function gut microbiota 16S rRNA sequencing rat

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Owing to advancements in non-invasive magnetic resonance imaging, many studies have repeatedly showed that diabetes affects the central nervous system in the presence of peripheral neuropathy, suggesting a common or interacting pathological mechanism for both complications.We aimed to investigate the role of abnormal gut microbiota in rats with diabetic peripheral neuropathy (DPN) combined with cognitive dysfunction. Glucose-compliant rats with nerve conduction deficits were screened as a successful group of DPN rats. The DPN group was then divided into rats with combined cognitive impairment (CD) and rats with normal cognitive function (NCD) based on the results of the Novel object recognition test. Rat feces were then collected for 16S rRNA gene sequencing of the intestinal flora.The results revealed that abnormalities in Firmicutes, Ruminococcaceae, Bacteroidia, and Actinobacteria-like microorganisms may induce DPN complicated by cognitive dysfunction.Copyright © 2023 Huang, Lin, Sun, Deng, Manyande, Xiang, Zhao and Hong.

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出版当年[2022]版：

大类 | 2 区

生物学

小类 | 2 区微生物学

最新[2025]版：

大类 | 2 区生物学

小类 | 3 区微生物学

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出版当年[2021]版：

Q1 MICROBIOLOGY

最新[2023]版：

Q2 MICROBIOLOGY

影响因子： 4 最新[2023版] 5.1 最新五年平均 6.064 出版当年[2021版] 6.843 出版当年五年平均 5.64 出版前一年[2020版] 5.2 出版后一年[2022版]

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第一作者单位： [1]Department of Anesthesiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

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