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MTAP-ANRIL gene fusion promotes melanoma epithelial-mesenchymal transition-like process by activating the JNK and p38 signaling pathways

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单位： [1]Department of Gastroenterology, Shangrao People's Hospital, Shangrao, 334000, Jiangxi Province, China. [2]Department of Gastroenterology,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030,Hubei Province,China. [3]Institute of Liver and Gastrointestinal Diseases,Huazhong University of Science and Technology,Tongji Hospital of Tongji Medical CollegeWuhan,430030,Hubei Province,China. [4]Department of Otolaryngology-Head and Neck Surgery,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030,Hubei Province,China

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Gene fusions caused by cytogenetic aberrations play important roles in the initiation and progression of cancers. The recurrent MTAP-ANRIL fusion gene was reported to have a frequency of greater than 7% in melanoma in our previous study. However, its functions remain unclear. Truncated MTAP proteins resulting from point mutations in the last three exons of MTAP can physically interact with the wild-type MTAP protein, a tumor suppressor in several human cancers. Similarly, MTAP-ANRIL, which is translated into a truncated MTAP protein, would influence wild-type MTAP to act as an oncogene. Here, we found that MTAP-ANRIL gene fusion downregulated the expression of wild-type MTAP and promoted epithelial-mesenchymal transition-like process through the activation of JNK and p38 MAPKs in vitro and in vivo. Our results suggest that MTAP-ANRIL is a potential molecular prognostic biomarker and therapeutic target for melanoma.© 2023. The Author(s).

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出版当年[2022]版：

大类 | 3 区综合性期刊

小类 | 3 区综合性期刊

最新[2025]版：

大类 | 3 区综合性期刊

小类 | 3 区综合性期刊

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出版当年[2021]版：

Q2 MULTIDISCIPLINARY SCIENCES

最新[2023]版：

Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 3.8 最新[2023版] 4.3 最新五年平均 4.997 出版当年[2021版] 5.516 出版当年五年平均 4.38 出版前一年[2020版] 4.6 出版后一年[2022版]

第一作者：

第一作者单位： [1]Department of Gastroenterology, Shangrao People's Hospital, Shangrao, 334000, Jiangxi Province, China.

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通讯机构： [2]Department of Gastroenterology,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030,Hubei Province,China. [3]Institute of Liver and Gastrointestinal Diseases,Huazhong University of Science and Technology,Tongji Hospital of Tongji Medical CollegeWuhan,430030,Hubei Province,China.

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