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Associations of Serum 25(OH)D with Risk of Recurrent Cardiovascular Events in Individuals with Coronary Heart Disease

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收录情况： ◇ SCIE

作者：
Lin Xiaoyu[1] * ; Chen Xue[1] ; Liu Sen[1] ; Deng Yulei[2] ; Wang Yuexuan[3] ; Lu Qi[1] ; Li Rui[1] ; Ou Yunjing[1] ; Tian Qingying[1] ; Liao Yunfei[4] ; Cui Guanglin[5] ; Yang Kun[6] ; Pan An[7] ; Liu Gang[1,*1] ;
单位： [1]Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety (Huazhong University of Science and Technology), Ministry of Education Key Lab of Environment and Health, and State Key Laboratory of Environment Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [2]Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [3]Department of Applied Statistics, Johannes Kepler Universit鋞 Linz, Linz 4040, Austria [4]Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [5]Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [6]Department of Endocrinology, Affiliated Dongfeng Hospital, Hubei University of Medicine, Shiyan 442008, China [7]Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
出处：
DOI： 10.1210/clinem/dgad339
ISSN：

摘要：
Few studies have examined the relationship between vitamin D and the risk of recurrent cardiovascular events in people with coronary heart disease (CHD).This study aimed to investigate the associations of serum 25-hydroxyvitamin D [25(OH)D] concentration and the vitamin D receptor (VDR) polymorphisms with the risk of recurrent cardiovascular events in individuals with established CHD.A total of 22,571 participants with CHD were included from the UK Biobank. Recurrent cardiovascular events, including myocardial infarction (MI), heart failure (HF), stroke, and CVD mortality, were identified from electronic health records. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).The median (interquartile range) of serum 25(OH)D concentration was 44.8 (30.3, 61.4) nmol/L, and 58.6% of participants had 25(OH)D below 50 nmol/L. During a median follow-up of 11.2 years, a total of 3,998 recurrent cardiovascular events were documented. After multivariable adjustment, there was a non-linear inverse relationship between serum 25(OH)D and recurrent cardiovascular events (P non-linearity <0.01), and the decreasing risk gradually leveled off at around 50 nmol/L. Compared with participants with serum 25(OH)D <25.0 nmol/L, the HRs (95% CIs) for participants with serum 25(OH)D of 50.0-74.9 nmol/L were 0.64 (0.58, 0.71) for recurrent cardiovascular events, 0.78 (0.65, 0.94) for MI, 0.66 (0.57, 0.76) for HF, and 0.66 (0.52, 0.84) for stroke. In addition, these associations were not modified by genetic variants in the VDR.In people with established CHD, higher serum 25(OH)D concentrations were non-linearly associated with a lower risk of recurrent cardiovascular events, with a potential threshold around 50 nmol/L. These findings highlight the importance of maintaining adequate vitamin D status in the prevention of recurrent cardiovascular events among individuals with CHD.© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

基金：
G.L. was supported by the National Natural Science Foundation of China (82273623 and 82073554), the HubeiProvince Science Fund for Distinguished Young Scholars (2021CFA048), and the Fundamental Research Funds for the Central Universities (2021GCRC076). A.P. is supported by the National Natural Science Foundation of China (81930124 and 82021005), and the Fundamental Research Funds for the Central Universities (2021GCRC075).
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外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 医学
小类 | 2 区 内分泌学与代谢
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 内分泌学与代谢
JCR分区：
出版当年[2021]版：
Q1 ENDOCRINOLOGY & METABOLISM
最新[2023]版：
Q1 ENDOCRINOLOGY & METABOLISM

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者单位： [1]Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety (Huazhong University of Science and Technology), Ministry of Education Key Lab of Environment and Health, and State Key Laboratory of Environment Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
通讯作者：
通讯机构： [1]Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety (Huazhong University of Science and Technology), Ministry of Education Key Lab of Environment and Health, and State Key Laboratory of Environment Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [*1]Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan 430030, China
推荐引用方式(GB/T 7714)：
Lin Xiaoyu,Chen Xue,Liu Sen,et al.Associations of Serum 25(OH)D with Risk of Recurrent Cardiovascular Events in Individuals with Coronary Heart Disease[J].JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM.2023,108(12):E1712-E1719.doi:10.1210/clinem/dgad339.
APA：
Lin Xiaoyu,Chen Xue,Liu Sen,Deng Yulei,Wang Yuexuan...&Liu Gang.(2023).Associations of Serum 25(OH)D with Risk of Recurrent Cardiovascular Events in Individuals with Coronary Heart Disease.JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,108,(12)
MLA：
Lin Xiaoyu,et al."Associations of Serum 25(OH)D with Risk of Recurrent Cardiovascular Events in Individuals with Coronary Heart Disease".JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 108..12(2023):E1712-E1719

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