单位：[1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.[2]Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.华中科技大学同济医学院附属同济医院[3]Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei Engineering Technology Center for Comprehensive Utilization of Medicinal Plants, College of Pharmacy Hubei University of Medicine, Shiyan 442000, People's Republic of China.
Spectasterols A-E (1-5), aromatic ergosterols with unique ring systems, were isolated from Aspergillus spectabilis. Compounds 1 and 2 possess a 6/6/6/5/5 ring system with an additional cyclopentene, while 3 and 4 have an uncommon 6/6/6/6 ring system generated by the D-ring expansion via 1,2-alkyl shifts. Compound 3 exhibited cytotoxic activity (IC50 6.9 μM) and induced cell cycle arrest and apoptosis in HL60 cells. Compound 3 was anti-inflammatory; it decreased COX-2 levels at the transcription and protein levels and inhibited the nuclear translocation of NF-κB p65.
基金：
This work was financially supported by the Program for
Changjiang Scholars of Ministry of Education of the People’s
Republic of China (T2016088); the National Natural Science
Foundation for Distinguished Young Scholars (81725021); the
National Natural Science Foundation for Excellent Young
Scholars (81922065); Innovative Research Groups of the
National Natural Science Foundation of China (81721005);
the National Natural Science Foundation of China
(82104043); the Science and Technology Major Project of
Hubei Province (2021ACA012); the Research and Development
Program of Hubei Province (2020BCA058); the
Integrated Innovative Team for Major Human Diseases
Program of Tongji Medical College (HUST); and the Tongji-Rongcheng Center for Biomedicine (HUST).
第一作者单位：[1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
共同第一作者：
通讯作者：
通讯机构：[1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.[*1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China
推荐引用方式(GB/T 7714)：
Wei Mengsha,Huang Liping,Li Qin,et al.Spectasterols, Aromatic Ergosterols with 6/6/6/5/5, 6/6/6/6, and 6/6/6/5 Ring Systems from Aspergillus spectabilis[J].JOURNAL OF NATURAL PRODUCTS.2023,86(6):1385-1391.doi:10.1021/acs.jnatprod.2c01034.
APA：
Wei Mengsha,Huang Liping,Li Qin,Qiao Xinyi,Zhao Ziming...&Zhang Yonghui.(2023).Spectasterols, Aromatic Ergosterols with 6/6/6/5/5, 6/6/6/6, and 6/6/6/5 Ring Systems from Aspergillus spectabilis.JOURNAL OF NATURAL PRODUCTS,86,(6)
MLA：
Wei Mengsha,et al."Spectasterols, Aromatic Ergosterols with 6/6/6/5/5, 6/6/6/6, and 6/6/6/5 Ring Systems from Aspergillus spectabilis".JOURNAL OF NATURAL PRODUCTS 86..6(2023):1385-1391
