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The role of regulated necrosis in inflammation and ocular surface diseases

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单位: [1]Department of Ophthalmology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,430030,China
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关键词: Pyroptosis Ferroptosis Necroptosis Inflammation Ocular surface diseases

摘要:
In recent decades, numerous types of regulated cell death have been identified, including pyroptosis, ferroptosis and necroptosis. Regulated necrosis is characterized by a series of amplified inflammatory responses that result in cell death. Therefore, it has been suggested to play an essential role in the pathogenesis of ocular surface diseases. The cell morphological features and molecular mechanisms of regulated necrosis are discussed in this review. Furthermore, it summarizes the role of ocular surface diseases, such as dry eye, keratitis, and cornea alkali burn, as potential disease prevention and treatment targets.Copyright © 2023 Elsevier Ltd. All rights reserved.

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出版当年[2022]版:
大类 | 3 区 医学
小类 | 2 区 眼科学
最新[2025]版:
大类 | 3 区 医学
小类 | 2 区 眼科学
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出版当年[2021]版:
Q2 OPHTHALMOLOGY
最新[2023]版:
Q1 OPHTHALMOLOGY

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第一作者单位: [1]Department of Ophthalmology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,430030,China
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