个人科研网厅 | | 帮助
高级检索
当前位置： 首页 > 详情页

Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes

| 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE ◇ 自然指数

作者：
Liu Nana[1] * ; Zhang Longjiang[2] ; Tian Tian[3] ; Cheng Jingliang[4] ; Zhang Bing[5] ; Qiu Shijun[6] ; Geng Zuojun[7] ; Cui Guangbin[8] ; Zhang Quan[9] ; Liao Weihua[10,11,12] ; Yu Yongqiang[13] ; Zhang Hui[14] ; Gao Bo[15,16] ; Xu Xiaojun[17] ; Han Tong[18] ; Yao Zhenwei[19] ; Qin Wen[1] ; Liu Feng[1] ; Liang Meng[20] ; Xu Qiang[1] ; Fu Jilian[1] ; Xu Jiayuan[1] ; Zhu Wenzhen[3] ; Zhang Peng[21] ; Li Wei[21] ; Shi Dapeng[22] ; Wang Caihong[4] ; Lui Su[23] ; Yan Zhihan[24] ; Chen Feng[25] ; Li Jiance[26] ; Zhang Jing[27,28] ; Wang Dawei[29] ; Shen Wen[30] ; Miao Yanwei[31] ; Xian Junfang[32] ; Gao Jia-Hong[33] ; Zhang Xiaochu[34] ; Li Mulin Jun[35] ; Xu Kai[36] ; Zuo Xi-Nian[37,38] ; Wang Meiyun[39] ; Ye Zhaoxiang[40] ; Yu Chunshui[41,42] ; ;
单位： [1]Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China. [2]Department of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. [3]Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [4]Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. [5]Department of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China. [6]Department of Medical Imaging, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China. [7]Department of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, China. [8]Functional and Molecular Imaging Key Lab of Shaanxi Province & Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi'an, China. [9]Department of Radiology, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin, China. [10]Department of Radiology, Xiangya Hospital, Central South University, Changsha, China. [11]Molecular Imaging Research Center of Central South University, Changsha, China. [12]National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. [13]Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. [14]Department of Radiology, The First Hospital of Shanxi Medical University, Taiyuan, China. [15]Department of Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China. [16]Department of Radiology, Yantai Yuhuangding Hospital, Yantai, China. [17]Department of Radiology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China. [18]Department of Radiology, Tianjin Huanhu Hospital, Tianjin, China. [19]Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China. [20]School of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, China. [21]Department of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China. [22]Department of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, Zhengzhou, China. [23]Department of Radiology, Huaxi MR Research Center (HMRRC), Functional and Molecular lmaging key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China. [24]Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China. [25]Department of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China. [26]Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. [27]Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China. [28]Gansu Province Clinical Research Center for Functional and Molecular Imaging, Lanzhou, China. [29]Department of Radiology, Qilu Hospital of Shandong University, Jinan, China. [30]Department of Radiology, Tianjin First Center Hospital, Tianjin, China. [31]Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China. [32]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [33]Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China. [34]Division of Life Science and Medicine, University of Science & Technology of China, Hefei, China. [35]Department of Bioinformatics, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China. [36]Department of Radiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China. [37]Developmental Population Neuroscience Research Center at IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China. [38]Institute of Psychology, Chinese Academy of Sciences, Beijing, China. [39]Department of Radiology, Henan Provincial People's Hospital & Zhengzhou University People's Hospital, Zhengzhou, China. mywang@ha.edu.cn. [40]Department of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China. yezhaoxiang@163.com. [41]Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China. chunshuiyu@tmu.edu.cn. [42]CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China. chunshuiyu@tmu.edu.cn.
出处：
DOI： 10.1038/s41588-023-01425-8
ISSN：

摘要：
The hippocampus is critical for memory and cognition and neuropsychiatric disorders, and its subfields differ in architecture and function. Genome-wide association studies on hippocampal and subfield volumes are mainly conducted in European populations; however, other ancestral populations are under-represented. Here we conduct cross-ancestry genome-wide association meta-analyses in 65,791 individuals for hippocampal volume and 38,977 for subfield volumes, including 7,009 individuals of East Asian ancestry. We identify 339 variant-trait associations at P < 1.13 × 10-9 for 44 hippocampal traits, including 23 new associations. Common genetic variants have similar effects on hippocampal traits across ancestries, although ancestry-specific associations exist. Cross-ancestry analysis improves the fine-mapping precision and the prediction performance of polygenic scores in under-represented populations. These genetic variants are enriched for Wnt signaling and neuron differentiation and affect cognition, emotion and neuropsychiatric disorders. These findings may provide insight into the genetic architectures of hippocampal and subfield volumes.© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.

语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 生物学
小类 | 1 区 遗传学
最新[2025]版：
大类 | 1 区 生物学
小类 | 1 区 遗传学
JCR分区：
出版当年[2021]版：
Q1 GENETICS & HEREDITY
最新[2023]版：
Q1 GENETICS & HEREDITY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者单位： [1]Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China.
推荐引用方式(GB/T 7714)：
Liu Nana,Zhang Longjiang,Tian Tian,et al.Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes[J].NATURE GENETICS.2023,55(7):1126-+.doi:10.1038/s41588-023-01425-8.
APA：
Liu Nana,Zhang Longjiang,Tian Tian,Cheng Jingliang,Zhang Bing...&.(2023).Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes.NATURE GENETICS,55,(7)
MLA：
Liu Nana,et al."Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes".NATURE GENETICS 55..7(2023):1126-+

资源点击量：589 今日访问量：0 总访问量：441 更新日期：2025-06-01 建议使用谷歌、火狐浏览器 常见问题

版权所有：重庆聚合科技有限公司 渝ICP备12007440号-3 地址：重庆市两江新区泰山大道西段8号坤恩国际商务中心16层（401121）