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Hemostasis-osteogenesis integrated Janus carboxymethyl chitin/hydroxyapatite porous membrane for bone defect repair

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单位： [1]Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, PR China [2]Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing, Yantai 264005, PR China [3]Department of Orthopaedic Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,PR China

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Barrier membranes with osteogenesis are desirable for promoting bone repair. Janus membrane, which has a bilayered structure with different properties on each side, could meet the osteogenesis/barrier dual functions of guided bone regeneration. In this work, new biodegradable Janus carboxymethyl chitin membrane with asymmetric pore structure was prepared based on thermosensitive carboxymethyl chitin without using any crosslinkers. Nano-hydroxyapatites were cast on single-sided membrane. The obtained carboxymethyl chitin/nano-hydroxyapatite Janus membrane showed dual biofunctions: the dense layer of the Janus membrane could act as a barrier to prevent connective tissue cells from invading the bone defects, while the porous layer (with pore size 100-200 μm) containing nano-hydroxyapatite could guide bone regeneration. After implanted on the rat critical-sized calvarial defect 8 weeks, carboxymethyl chitin/nano-hydroxyapatite membrane showed the most newly formed bone tissue with the highest bone volume/total volume ratio (10.03 ± 1.81 %, analyzed by micro CT), which was significantly better than the commercial collagen membrane GTR® (5.05 ± 0.76 %). Meanwhile, this Janus membrane possessed good hemostatic ability. These results suggest a facile strategy to construct hemostasis-osteogenesis integrated Janus carboxymethyl chitin/hydroxyapatite membrane for guided bone regeneration.Copyright © 2023. Published by Elsevier Ltd.

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出版当年[2022]版：

大类 | 1 区

化学

小类 | 1 区应用化学 1 区高分子科学 1 区有机化学

最新[2025]版：

大类 | 1 区

化学

小类 | 1 区应用化学 1 区有机化学 1 区高分子科学

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出版当年[2021]版：

Q1 CHEMISTRY, APPLIED Q1 CHEMISTRY, ORGANIC Q1 POLYMER SCIENCE

最新[2023]版：

Q1 CHEMISTRY, APPLIED Q1 CHEMISTRY, ORGANIC Q1 POLYMER SCIENCE

影响因子： 10.7 最新[2023版] 10.3 最新五年平均 10.723 出版当年[2021版] 9.964 出版当年五年平均 9.381 出版前一年[2020版] 11.2 出版后一年[2022版]

第一作者：

第一作者单位： [1]Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, PR China [2]Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing, Yantai 264005, PR China

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通讯作者：

通讯机构： [1]Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, PR China [3]Department of Orthopaedic Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,PR China [*1]Department of Orthopedic Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,1095 Jiefang Avenue,Wuhan 430030,PR China [*2]Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, 299 Bayi Road, Wuhan 430072, PR China

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