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Quantitative application of dual-phase 99mTc-sestamibi SPECT/CT imaging of parathyroid lesions: identification of optimal timing in secondary hyperparathyroidism

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单位： [1]Department of Nuclear Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan 030032, China [2]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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In this retrospective study, we compared the maximum standardized uptake values (SUVmax) of parathyroid lesions and the target-to-background ratio (TBR) of parathyroid lesions to thyroid tissue in early-phase single-photon emission computed tomography/computed tomography (SPECT/CT) versus delayed-phase SPECT/CT in patients with secondary hyperparathyroidism (SHPT) in order to determine the optimal timing of 99mTc- methoxyisobutylisonitrile (99mTc-MIBI) SPECT/CT imaging.Seventeen patients with a history of chronic kidney failure stage 5 on hemodialysis, underwent pre-operative parathyroid scintigraphy for detection and localization of parathyroid lesions. Retrospective analysis was conducted for lesions with focal accumulation of 99mTc-MIBI. All patients underwent dual-phase 99mTc-MIBI parathyroid scintigraphy and dual-phase SPECT/CT. SUVmax of parathyroid lesions and thyroid tissues was measured.Mean SUVmax of parathyroid lesions was 4.86 on early-phase and 2.58 on delayed-phase SPECT/CT, respectively. Mean TBR was 1.14 on early phase and 1.48 on delayed-phase SPECT/CT, respectively. Statistically significant differences in SUVmax and TBR between dual-phase SPECT/CT were observed (P < 0.001).Delayed-phase SPECT/CT in SHPT is required because of the better image contrast.© 2023. The Author(s).

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出版当年[2022]版：

大类 | 2 区医学

小类 | 2 区核医学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区核医学

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出版当年[2021]版：

Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

最新[2023]版：

Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子： 3 最新[2023版] 3.7 最新五年平均 4.654 出版当年[2021版] 4.956 出版当年五年平均 3.309 出版前一年[2020版] 4 出版后一年[2022版]

第一作者：

第一作者单位： [1]Department of Nuclear Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan 030032, China [2]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

通讯作者：

通讯机构： [1]Department of Nuclear Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan 030032, China [2]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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