单位：[1]Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science Technology, Wuhan, Hubei, China.[2]Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.华中科技大学同济医学院附属同济医院[3]Cytek Biosciences, R&D Clinical Reagents, Fremont, CA, United States.[4]Laboratory of Immunochemistry, National Research Center Institute of Immunology, Federal Medical Biological Agency of Russia, 115522, Moscow, Russia.[5]Division of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.[6]Institut de Recherche Saint-Louis, Université de Paris, Paris, France.[7]Laboratory of Human Immunology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo - SP, Brazil.
The persistent pandemic of coronavirus disease in 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) currently poses a major infectious threat to public health around the world. COVID-19 is an infectious disease characterized by strong induction of inflammatory cytokines, progressive lung inflammation, and potential multiple organ dysfunction. SARS-CoV-2 infection is closely related to the innate immune system and adaptive immune system. Dendritic cells (DCs), as a "bridge" connecting innate immunity and adaptive immunity, play many important roles in viral diseases. In this review, we will pay special attention to the possible mechanism of dendritic cells in human viral transmission and clinical progression of diseases, as well as the reduction and dysfunction of DCs in severe SARS-CoV-2 infection, so as to understand the mechanism and immunological characteristics of SARS-CoV-2 infection.
基金：
This work was supported by R&D Program of Guangzhou Laboratory, Grant, No. SRPG22-006, National Natural Science Foundation of China (31970839, 32100709), China Postdoctoral Science Foundation (2020M682419), HUST Academic Frontier Youth Team (2018QYTD10), and Medjaden Academy & Research Foundation for Young Scientists (MJR20221009, MJR20221030).
第一作者单位：[1]Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science Technology, Wuhan, Hubei, China.[2]Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Xuying,Guan Fei,Miller Heather,et al.The role of dendritic cells in COVID-19 infection[J].EMERGING MICROBES & INFECTIONS.2023,12(1):doi:10.1080/22221751.2023.2195019.
APA：
Wang Xuying,Guan Fei,Miller Heather,Byazrova Maria G,Cndotti Fabio...&Liu Chaohong.(2023).The role of dendritic cells in COVID-19 infection.EMERGING MICROBES & INFECTIONS,12,(1)
MLA：
Wang Xuying,et al."The role of dendritic cells in COVID-19 infection".EMERGING MICROBES & INFECTIONS 12..1(2023)
医学