单位：[1]Oil Crops Research Institute of Chinese Academy of Agricultural Sciences, Key Laboratory of Biology and Genetic Improvement of Oil Crops, Key Laboratory of Detection for Mycotoxins, Wuhan, 430062, PR China[2]Hubei Hongshan Lab, Wuhan, 430070, PR China[3]Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430030, PR China华中科技大学同济医学院附属同济医院[4]Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, 10900, Thailand[5]Institute of Sciences of Food Production, National Research Council, Bari, 70125, Italy[6]Key Laboratory of Agro-products Quality and Safety of Xinjiang, Laboratory of Quality and Safety Risk Assessment for Agro-Products (Urumqi), Ministry of Agriculture and Rural Affairs, Urumqi, 830091, PR China
Mycotoxins, hazardous fungi, and their metabolites have caused a heavy burden on the environment, food safety, and health care by inducing acute death, cancer, and organ necrosis. Reliable and precise detection can efficiently identify their existence and explore their metabolism. This work focuses on determining mycotoxins, fungi, and their metabolites via mass spectrometry (MS) techniques. Sample preparation techniques for mycotoxins and fungi were evaluated. The identification of mycotoxins and the hazardous metabolism of fungi in humans, plants, and animals are critically discussed. The merits of diversified MS techniques and their sensitivity and feasibility are discussed. Finally, challenges and op-portunities are suggested. This work highlights the application of MS in determining mycotoxins, haz-ardous fungi, and their metabolites and contributes to analytical chemistry, food safety, environmental monitoring, and health care.(c) 2023 Elsevier B.V. All rights reserved.
基金：
Natural Science Foundation of China [32072331, 32102084]; Natural Science Foundation of Hubei Prov ince [2020CFB731]; International Science and Technology Cooperation Project of Hubei [2022EHB041]; Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences [ACCS-ASTIP-2021-OCRI]; Hubei Hongshan Laboratory
第一作者单位：[1]Oil Crops Research Institute of Chinese Academy of Agricultural Sciences, Key Laboratory of Biology and Genetic Improvement of Oil Crops, Key Laboratory of Detection for Mycotoxins, Wuhan, 430062, PR China[2]Hubei Hongshan Lab, Wuhan, 430070, PR China
通讯作者：
通讯机构：[1]Oil Crops Research Institute of Chinese Academy of Agricultural Sciences, Key Laboratory of Biology and Genetic Improvement of Oil Crops, Key Laboratory of Detection for Mycotoxins, Wuhan, 430062, PR China[2]Hubei Hongshan Lab, Wuhan, 430070, PR China[*1]Oil Crops Research Institute of Chinese Academy of Agricultural Sciences, Xudong 2nd Road, Wuhan, 430062, PR China
推荐引用方式(GB/T 7714)：
Zhao Yuan,Chen Di,Duan Hongyu,et al.Sample preparation and mass spectrometry for determining mycotoxins, hazardous fungi, and their metabolites in the environment, food, and healthcare[J].TRAC-TRENDS IN ANALYTICAL CHEMISTRY.2023,160:doi:10.1016/j.trac.2023.116962.
APA：
Zhao, Yuan,Chen, Di,Duan, Hongyu,Li, Peiwu,Wu, Wenqin...&Zhang, Zhaowei.(2023).Sample preparation and mass spectrometry for determining mycotoxins, hazardous fungi, and their metabolites in the environment, food, and healthcare.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,160,
MLA：
Zhao, Yuan,et al."Sample preparation and mass spectrometry for determining mycotoxins, hazardous fungi, and their metabolites in the environment, food, and healthcare".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 160.(2023)
：
化学