The Golgi apparatus is one of the important organelles, where the final processing and packaging of cellular secretions (such as proteins) are completed. The disorder of Golgi apparatus structure and function will induce many diseases. Therefore, monitoring the morphological structure of Golgi apparatus is crucial for the diagnosis and treatment of relevant diseases. In order to achieve Golgi apparatus-targeting imaging, the strategy of targeting unit inheritance was adopted and carbon dots (CDs) with Golgi apparatus-targeting ability were synthesized by one-step hydrothermal method with L-ascorbic acid with high reactivity and reducibility as the carbon source and L-cysteine as the targeting unit. CDs have a certain amount of cysteine residues on their surface, and have excitation dependence, satisfactory fluorescence and cysteine residues stability and low toxicity. As an imaging agent, CDs can be used for targeting imaging of Golgi apparatus.
基金：
National Natural Science Foundation of China [82172048, U21A20378]; Natural Science Foundation of Shanxi Province [202103021223439, 201901D111419]; Shanxi Technology Innovation Center for Controlled and Sustained Release of Nano-drugs [SD2218]; Doctoral Starting Foundation of Shanxi Province [202201-1]; Doctoral Foundation of the Second Hospital of Shanxi Medical University [5-2-1-A-5]; Collaborative Innovation Center of R&D molecular diagnosis, Treatment Technology and targeted drugs for cancer of Shanxi Medical University [2021SX-FR010]; Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering; [202104010911026]
第一作者单位：[1]Shanxi Med Univ, Clin Med Coll 2, Intervent Treatment Dept, Second Hosp, Taiyuan 030001, Peoples R China
通讯作者：
通讯机构：[2]Shanxi Med Univ, Shanxi Bethune Hosp, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Hosp 3,Ophthalmol Dept, Taiyuan 030032, Peoples R China[3]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Peoples R China
推荐引用方式(GB/T 7714)：
Wei Yingying,Gao Yuduan,Chen Lin,et al.Carbon dots based on targeting unit inheritance strategy for Golgi apparatus-targeting imaging[J].FRONTIERS OF MATERIALS SCIENCE.2023,17(1):doi:10.1007/s11706-023-0627-y.
APA：
Wei, Yingying,Gao, Yuduan,Chen, Lin,Li, Qiang,Du, Jinglei...&Yang, Yongzhen.(2023).Carbon dots based on targeting unit inheritance strategy for Golgi apparatus-targeting imaging.FRONTIERS OF MATERIALS SCIENCE,17,(1)
MLA：
Wei, Yingying,et al."Carbon dots based on targeting unit inheritance strategy for Golgi apparatus-targeting imaging".FRONTIERS OF MATERIALS SCIENCE 17..1(2023)
