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Identification and Verification of Potential Biomarkers in Renal Ischemia-Reperfusion Injury by Integrated Bioinformatic Analysis

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收录情况： ◇ SCIE

作者：
Pan Ziwen[1] * ; Yang Yuanyuan[1] ; Cao Rui[1] ; Qiu Yang[1] ; Li Shanglin[1] ; Zhao Yuanyuan[1] ; Chang Sheng[1] ; Chen Song[1] ; Chen Zhishui[1] ; Zhang Weijie[1] ; Zhao Daqiang[1] ;
单位： [1]Institute of Organ Transplantation,Tongji Hospital,Key Laboratory of Organ Transplantation,Ministry of Education,NHC Key Laboratory of Organ Transplantation,Key Laboratory of Organ Transplantation,Chinese Academy of Medical Sciences,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.
出处：
DOI： 10.1155/2023/7629782
ISSN：

摘要：
Renal ischemia-reperfusion injury (RIRI) plays an important role in the poor prognosis of patients with renal transplants. However, the potential targets and mechanism of IRI are still unclear.Differential gene expression (DEG) analysis and weighted correlation network analysis (WGCNA) were performed on the GSE27274 dataset. Pathway enrichment analysis on the DEGs was performed. To identify the hub DEGs, we constructed a protein-protein interaction (PPI) network. Finally, the hub genes were verified, and candidate drugs were screened from the DsigDB database.A hundred DEGs and four hub genes (Atf3, Psmb6, Psmb8, and Psmb10) were screened out. Pathway enrichment analysis revealed that 100 DEGs were mainly enriched in apoptosis and the TNF signaling pathway. The four hub genes were verified in animal models and another dataset (GSE148420). Thereafter, a PPI network was used to identify the four hub genes (Atf3, Psmb6, Psmb8, and Psmb10). Finally, eight candidate drugs were identified as potential drugs.Three hub genes (Psmb6, Psmb8, and Psmb10) were associated with RIRI and could be potential novel biomarkers for RIRI.Copyright © 2023 Ziwen Pan et al.

基金：
Non-Profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2019PT320014), Key Support Project of Scientific Research Project of Health and Family Planning Commission of Hubei Province (wj2019z007), and China Organ Transplantation Foundation “Transplant Pioneer Plan” Project 2020.
语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 生物学
小类 | 3 区 生物工程与应用微生物 4 区 医学：研究与实验
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 生物工程与应用微生物 4 区 医学：研究与实验
JCR分区：
出版当年[2021]版：
Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q3 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q3 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版]

第一作者：
第一作者单位： [1]Institute of Organ Transplantation,Tongji Hospital,Key Laboratory of Organ Transplantation,Ministry of Education,NHC Key Laboratory of Organ Transplantation,Key Laboratory of Organ Transplantation,Chinese Academy of Medical Sciences,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.
通讯作者：
推荐引用方式(GB/T 7714)：
Pan Ziwen,Yang Yuanyuan,Cao Rui,et al.Identification and Verification of Potential Biomarkers in Renal Ischemia-Reperfusion Injury by Integrated Bioinformatic Analysis[J].BIOMED RESEARCH INTERNATIONAL.2023,2023:7629782.doi:10.1155/2023/7629782.
APA：
Pan Ziwen,Yang Yuanyuan,Cao Rui,Qiu Yang,Li Shanglin...&Zhao Daqiang.(2023).Identification and Verification of Potential Biomarkers in Renal Ischemia-Reperfusion Injury by Integrated Bioinformatic Analysis.BIOMED RESEARCH INTERNATIONAL,2023,
MLA：
Pan Ziwen,et al."Identification and Verification of Potential Biomarkers in Renal Ischemia-Reperfusion Injury by Integrated Bioinformatic Analysis".BIOMED RESEARCH INTERNATIONAL 2023.(2023):7629782

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