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The clinical and immunological characteristics in fatal severe fever with thrombocytopenia syndrome virus (SFTSV) infection

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收录情况： ◇ SCIE

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单位： [1]Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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关键词： Severe fever with thrombocytopenia syndrome Lymphocyte Immunological indicators Hemophagocytic lymphohistiocytosis Prognosis

摘要：

This study aimed to make a comprehensive evaluation of peripheral immune profiles for further understanding the immunopathogenesis of severe fever with thrombocytopenia syndrome (SFTS).Forty-seven patients with SFTS virus infection were included, of which 24 were deceased. The percentages, absolute numbers, phenotype of lymphocyte subsets were detected by flow cytometry.In patients with SFTS, the numbers of CD3+T, CD4+T, CD8+T and NKT cells were decreased compared with healthy controls (HCs), accompanied with highly active and exhausted phenotypes for T cells, and overproliferating plasmablasts. High inflammatory status, dysregulation of coagulation and host immune response were more obvious in deceased patients than that of survivors. Higher levels of PCT, IL-6, IL-10, TNF-α, APTT, TT and the occurrence of hemophagocytic lymphohistiocytosis were poor prognostic indicators of SFTS.The evaluation of immunological markers in combination with laboratory tests has critical value for selecting prognostic markers and potential treatment target.Copyright © 2023. Published by Elsevier Inc.

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出版当年[2022]版：

大类 | 3 区医学

小类 | 3 区免疫学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区免疫学

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出版当年[2021]版：

Q1 IMMUNOLOGY

最新[2023]版：

Q2 IMMUNOLOGY

影响因子： 4.5 最新[2023版] 4.7 最新五年平均 10.19 出版当年[2021版] 6.592 出版当年五年平均 3.969 出版前一年[2020版] 8.6 出版后一年[2022版]

第一作者：

第一作者单位： [1]Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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通讯机构： [1]Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [*1]Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road 1095, Wuhan 430030, China

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