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Long non-coding RNA signature in colorectal cancer: research progression and clinical application

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收录情况： ◇ SCIE

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单位： [1]GI Cancer Research Institute,Tongji Hospital,Huazhong University of Science and Technology,Wuhan,People's Republic of China. [2]Department of Gastrointestinal Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,1095 Jiefang Avenue,Wuhan,430030,People's Republic of China

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关键词： colorectal cancer Long non-coding RNA Diagnosis Biomarker

摘要：

Colorectal cancer is one of the top-ranked human malignancies. The development and progression of colorectal cancer are associated with aberrant expression of multiple coding and non-coding genes. Long non-coding RNAs (lncRNAs) have an important role in regulating gene stability as well as gene expression. Numerous current studies have shown that lncRNAs are promising biomarkers and therapeutic targets for colorectal cancer. In this review, we have searched the available literature to list lncRNAs involved in the pathogenesis and regulation of colorectal cancer. We focus on the role of lncRNAs in cancer promotion or suppression, their value in tumor diagnosis, and their role in treatment response and prognosis prediction. In addition, we will discuss the signaling pathways that these lncRNAs are mainly associated with in colorectal cancer. We also summarize the role of lncRNAs in colorectal precancerous lesions and colorectal cancer consensus molecular subgroups. We hope this review article will bring you the latest research progress and outlook on lncRNAs in colorectal cancer.© 2023. The Author(s).

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出版当年[2022]版：

大类 | 2 区医学

小类 | 3 区肿瘤学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

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出版当年[2021]版：

Q2 ONCOLOGY

最新[2023]版：

Q1 ONCOLOGY

影响因子： 5.3 最新[2023版] 5 最新五年平均 6.435 出版当年[2021版] 5.999 出版当年五年平均 5.722 出版前一年[2020版] 5.8 出版后一年[2022版]

第一作者：

第一作者单位： [1]GI Cancer Research Institute,Tongji Hospital,Huazhong University of Science and Technology,Wuhan,People's Republic of China. [2]Department of Gastrointestinal Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,1095 Jiefang Avenue,Wuhan,430030,People's Republic of China

通讯作者：

通讯机构： [1]GI Cancer Research Institute,Tongji Hospital,Huazhong University of Science and Technology,Wuhan,People's Republic of China. [2]Department of Gastrointestinal Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,1095 Jiefang Avenue,Wuhan,430030,People's Republic of China

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