单位：[1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People's Republic of China.[2]Huaxi MR Research Center, Department of Nuclear Medicine, Frontiers Science Center for Diseaserelated Molecular Network, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610000, Sichuan Province, People's Republic of China.四川大学华西医院[3]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People's Republic of China.华中科技大学同济医学院附属同济医院
Lasiodiplodiapyrones A and B (1 and 2), two new preussomerin derivatives, possessing an unexpected 6-methyl-4H-furo[3,2-c]pyran-4-one moiety and a highly functionalized conjoint and complicated polycyclic ring system, along with two known congeners (3 and 4), were isolated from the fungus Lasiodiplodia pseudotheobromae. Their structures including absolute configurations were determined by spectroscopic analyses, Mosher's method, and ECD calculations. A biosynthetic pathway was proposed to explain the origin of lasiodiplodiapyrones A and B as well as their relationship with preussomerins. Compounds 1-4 showed suppressive effects on the production of NO with IC50 values of 4.8 ± 0.3, 8.5 ± 1.1, 5.9 ± 0.8, and 12.8 ± 1.3 μM, respectively.
基金：
This work was financially supported by the Program for
Changjiang Scholars of Ministry of Education of the People’s
Republic of China (No. T2016088), the National Natural
Science Foundation for Distinguished Young Scholars
(81725021), the National Natural Science Foundation for
Excellent Young Scholars (81922065), the National Science
and Technology Project of China (2018ZX09201001-001-
003), Innovative Research Groups of the National Natural
Science Foundation of China (81721005), the National
Natural Science Foundation of China (31972865), the Science
and Technology Major Project of Hubei Province
(2021ACA012), the Research and Development Program of
Hubei Province (2020BCA058), the Natural Science Foundation
of Hubei Province (2021CFB362), the Academic Frontier
Youth Team of HUST (2017QYTD19), the Integrated
Innovative Team for Major Human Diseases Program of
Tongji Medical College (HUST), the Program from the China
Postdoctoral Science Foundation (2017M622460), and
Tongji-Rongcheng Center for Biomedicine, Huazhong University
of Science and Technology.
第一作者单位：[1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People's Republic of China.
共同第一作者：
通讯作者：
通讯机构：[1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People's Republic of China.[*1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 Hubei Province, People’s Republic of China
推荐引用方式(GB/T 7714)：
Liang Yu,Li Qin,Li Yongqi,et al.Lasiodiplodiapyrones A and B, Pyrone-Preussomerin Adducts with Highly Strained Polycyclic Ring Systems from Lasiodiplodia pseudotheobromae[J].JOURNAL OF NATURAL PRODUCTS.2023,86(1):18-23.doi:10.1021/acs.jnatprod.2c00530.
APA：
Liang Yu,Li Qin,Li Yongqi,Zheng Yuyi,Shen Yong...&Zhang Yonghui.(2023).Lasiodiplodiapyrones A and B, Pyrone-Preussomerin Adducts with Highly Strained Polycyclic Ring Systems from Lasiodiplodia pseudotheobromae.JOURNAL OF NATURAL PRODUCTS,86,(1)
MLA：
Liang Yu,et al."Lasiodiplodiapyrones A and B, Pyrone-Preussomerin Adducts with Highly Strained Polycyclic Ring Systems from Lasiodiplodia pseudotheobromae".JOURNAL OF NATURAL PRODUCTS 86..1(2023):18-23
