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Amino acids, microbiota-relatedmetabolites, and the risk of incident diabetes among normoglycemic Chinese adults: Findings from the 4C study

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收录情况： ◇ SCIE

作者：
Wang, Shuangyuan[1,2] * ; Li, Mian[1,2] ; Lin, Hong[1,2] ; Wang, Guixia[3] ; Xu, Yu[1,2] ; Zhao, Xinjie[4] ; Hu, Chunyan[1,2] ; Zhang, Yi[1,2] ; Zheng, Ruizhi[1,2] ; Hu, Ruying[5] ; Shi, Lixin[6] ; Du, Rui[1,2] ; Su, Qing[7] ; Wang, Jiqiu[1,2] ; Chen, Yuhong[1,2] ; Yu, Xuefeng[8] ; Yan, Li[9] ; Wang, Tiange[1,2] ; Zhao, Zhiyun[1,2] ; Liu, Ruixin[1,2] ; Wang, Xiaolin[4] ; Li, Qi[4] ; Qin, Guijun[10] ; Wan, Qin[11] ; Chen, Gang[12] ; Xu, Min[1,2] ; Dai, Meng[1,2] ; Zhang, Di[1,2] ; Tang, Xulei[13] ; Gao, Zhengnan[14] ; Shen, Feixia[15] ; Luo, Zuojie[16] ; Qin, Yingfen[16] ; Chen, Li[17] ; Huo, Yanan[18] ; Li, Qiang[19] ; Ye, Zhen[5] ; Zhang, Yinfei[20] ; Liu, Chao[21] ; Wang, Youmin[22] ; Wu, Shengli[23] ; Yang, Tao[24] ; Deng, Huacong[25] ; Zhao, Jiajun[26] ; Lai, Shenghan[27] ; Mu, Yiming[28] ; Chen, Lulu[29] ; Li, Donghui[30] ; Xu, Guowang[4] ; Ning, Guang[1,2] ; Wang, Weiqing[1,2] ; Bi, Yufang[1,2] ; Lu, Jieli[1,2] ;
单位： [1]Shanghai Jiao Tong Univ, Sch Med, Dept Endocrine & Metab Dis, Shanghai Inst Endocrine & Metab Dis,Ruijin Hosp, Shanghai, Peoples R China [2]Shanghai Jiao Tong Univ, Sch Med,Shanghai Natl Ctr Translat Med,Ruijin Hos, Ruijin Hosp,Key Lab Endocrine & Metab Dis,Natl Hl, Shanghai Natl Clin Res Ctr Endocrine & Metab Dis, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China [3]Jilin Univ, Hosp 1, Changchun, Peoples R China [4]Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China [5]Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Peoples R China [6]Guiyang Med Coll, Affiliated Hosp, Guiyang, Peoples R China [7]Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Shanghai, Peoples R China [8]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan, Peoples R China [9]Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou, Peoples R China [10]Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou, Peoples R China [11]Southwest Med Univ, Affiliated Hosp, Luzhou, Peoples R China [12]Fujian Med Univ, Fujian Prov Hosp, Fuzhou, Peoples R China [13]Lanzhou Univ, Hosp 1, Lanzhou, Peoples R China [14]Dalian Municipal Cent Hosp, Dalian, Peoples R China [15]Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou, Peoples R China [16]Guangxi Med Univ, Affiliated Hosp 1, Nanning, Peoples R China [17]Shandong Univ, Qilu Hosp, Jinan, Peoples R China [18]Nanchang Univ, Jiangxi Prov Peoples Hosp, Nanchang, Jiangxi, Peoples R China [19]Harbin Med Univ, Affiliated Hosp 2, Harbin, Peoples R China [20]Cent Hosp Shanghai Jiading Dist, Shanghai, Peoples R China [21]Jiangsu Prov Hosp Integrat Chinese & Western Med, Nanjing, Peoples R China [22]Anhui Med Univ, Affiliated Hosp 1, Hefei, Peoples R China [23]Karamay Municipal Peoples Hosp, Karamay, Xinjiang, Peoples R China [24]Nanjing Med Univ, Affiliated Hosp 1, Nanjing, Peoples R China [25]Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China [26]Shandong Univ, Shandong Prov Hosp, Jinan, Peoples R China [27]Johns Hopkins Univ, Sch Med, Baltimore, MD USA [28]Chinese Peoples Liberat Army Gen Hosp, Beijing, Peoples R China [29]Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Wuhan, Peoples R China [30]Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX 77030 USA
出处：
DOI： 10.1016/j.xcrm.2022.100727
ISSN：

摘要：
Although previous studies suggest that amino acids (AAs) and microbiota-related metabolites (MRMs) are associated with type 2 diabetes mellitus (T2DM), the results remain unclear among normoglycemic populations. We test 28 serum AAs and 22 MRMs in 3,414 subjects with incident diabetes and matched normoglycemic controls from the China Cardiometabolic Disease and Cancer Cohort (4C) Study. In fully adjusted logistic regression models, per SD increment of branched-chain AAs, aromatic AAs, asparagine, alanine, glutamic acid, homoserine, 2-aminoadipic acid, histidine, methionine, and proline are positively associated with incident T2DM. In the MRM panel, serum carnitines, N-acetyltryptophan, and uric acid are positively associated with incident T2DM. Causal mediation analyses indicate 34 significant causal mediation linkages, with 88.2% through obesity and lipids. Variances explained in the serum metabolites are modestly limited in the comprehensive catalog of risk factor-metabolite-diabetes associations. These findings reveal that systematic AAs and MRMs change profile before T2DM onset and support a potential role of metabolic alterations in the pathogenesis of diabetes.

基金：
National Natural Science Foundation of China [91857205, 82088102, 81930021, 81970728, 81970691, 82170819, 21904084]; Shanghai Outstanding Academic Leaders Plan [20XD1422800]; Shanghai Medical and Health Development Foundation [DMRFP_I_01]; Clinical Research Plan of SHDC [SHDC2020CR3064B, SHDC2020CR1001A]; Science and Technology Committee of Shanghai [20Y11905100, 19411964200]; Clinical Research Project of Shanghai Municipal Health Commission [20214Y0002]
语种：
外文
被引次数：
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出版当年[2021]版：
无
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 医学：研究与实验 2 区 细胞生物学
JCR分区：
出版当年[2020]版：
无
最新[2023]版：
Q1 CELL BIOLOGY Q1 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者单位： [1]Shanghai Jiao Tong Univ, Sch Med, Dept Endocrine & Metab Dis, Shanghai Inst Endocrine & Metab Dis,Ruijin Hosp, Shanghai, Peoples R China [2]Shanghai Jiao Tong Univ, Sch Med,Shanghai Natl Ctr Translat Med,Ruijin Hos, Ruijin Hosp,Key Lab Endocrine & Metab Dis,Natl Hl, Shanghai Natl Clin Res Ctr Endocrine & Metab Dis, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China
通讯作者：
通讯机构： [1]Shanghai Jiao Tong Univ, Sch Med, Dept Endocrine & Metab Dis, Shanghai Inst Endocrine & Metab Dis,Ruijin Hosp, Shanghai, Peoples R China [2]Shanghai Jiao Tong Univ, Sch Med,Shanghai Natl Ctr Translat Med,Ruijin Hos, Ruijin Hosp,Key Lab Endocrine & Metab Dis,Natl Hl, Shanghai Natl Clin Res Ctr Endocrine & Metab Dis, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China
推荐引用方式(GB/T 7714)：
Wang Shuangyuan,Li Mian,Lin Hong,et al.Amino acids, microbiota-relatedmetabolites, and the risk of incident diabetes among normoglycemic Chinese adults: Findings from the 4C study[J].CELL REPORTS MEDICINE.2022,3(9):doi:10.1016/j.xcrm.2022.100727.
APA：
Wang, Shuangyuan,Li, Mian,Lin, Hong,Wang, Guixia,Xu, Yu...&Lu, Jieli.(2022).Amino acids, microbiota-relatedmetabolites, and the risk of incident diabetes among normoglycemic Chinese adults: Findings from the 4C study.CELL REPORTS MEDICINE,3,(9)
MLA：
Wang, Shuangyuan,et al."Amino acids, microbiota-relatedmetabolites, and the risk of incident diabetes among normoglycemic Chinese adults: Findings from the 4C study".CELL REPORTS MEDICINE 3..9(2022)

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