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The effects and mechanism of taxanes on chemotherapy-associated ovarian damage: A review of current evidence

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Wu Chuqing[1,2,3] * ; Wu Tong[1,2,3] ; Chen Dan[1,2,3] ; Wei Simin[1,2,3] ; Tang Weicheng[1,2,3] ; Xue Liru[1,2,3] ; Xiong Jiaqiang[4] ; Huang Yibao[1,2,3] ; Guo Yican[1,2,3] ; Chen Ying[1,2,3] ; Wu Meng[1,2,3] ; Wang Shixuan[1,2,3] ;
单位： [1]Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China. [2]National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, Hubei, China. [3]Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Wuhan, Hubei, China. [4]Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
出处：
DOI： 10.3389/fendo.2022.1025018
ISSN：

关键词： taxanes chemotherapy ovarian function amenorrhea fertility preservation

摘要：
Chemotherapy is often a cause of premature ovarian insufficiency and infertility since the ovarian follicles are extremely sensitive to the effects of chemotherapeutic agents. Different chemotherapeutic agents with varying mechanisms of action may damage ovarian function differently. Taxanes are widely used in clinical cancer treatment, but the specific reproductive toxicological information is still controversial. This review described the impact and duration of taxanes on ovarian function in women and analyzed the possible reasons for different conclusions. Furthermore, the toxicity of taxanes on ovarian function and its possible mechanisms were discussed. The potential protective strategies and agents against ovarian damage induced by taxanes are also reviewed.Copyright © 2022 Wu, Wu, Chen, Wei, Tang, Xue, Xiong, Huang, Guo, Chen, Wu and Wang.

基金：
National Natural Science Foundation of China (no. 81873824, 82001514) and the Fundamental Research Funds for the Central Universities (HSUT: 2021yjsCXCY087).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 3 区 医学
小类 | 3 区 内分泌学与代谢
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 内分泌学与代谢
JCR分区：
出版当年[2020]版：
Q1 ENDOCRINOLOGY & METABOLISM
最新[2023]版：
Q2 ENDOCRINOLOGY & METABOLISM

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者单位： [1]Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China. [2]National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, Hubei, China. [3]Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Wuhan, Hubei, China.
通讯作者：
通讯机构： [1]Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China. [2]National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, Hubei, China. [3]Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Wuhan, Hubei, China.
推荐引用方式(GB/T 7714)：
Wu Chuqing,Wu Tong,Chen Dan,et al.The effects and mechanism of taxanes on chemotherapy-associated ovarian damage: A review of current evidence[J].FRONTIERS IN ENDOCRINOLOGY.2022,13:1025018.doi:10.3389/fendo.2022.1025018.
APA：
Wu Chuqing,Wu Tong,Chen Dan,Wei Simin,Tang Weicheng...&Wang Shixuan.(2022).The effects and mechanism of taxanes on chemotherapy-associated ovarian damage: A review of current evidence.FRONTIERS IN ENDOCRINOLOGY,13,
MLA：
Wu Chuqing,et al."The effects and mechanism of taxanes on chemotherapy-associated ovarian damage: A review of current evidence".FRONTIERS IN ENDOCRINOLOGY 13.(2022)

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