Myeloid-derived suppressor cells (MDSCs) are a group of immature and heterogeneous myeloid cells with immunosuppressive functions. MDSCs play important roles in the pathogenesis of cancer, chronic inflammatory diseases, and many autoimmune disorders. The accumulation and activation of MDSCs can be regulated by tumor necrosis factor alpha (TNF-alpha). In this review, we summarize the roles played by TNF-alpha in the recruitment, immunosuppressive functions, and chemotaxis of MDSCs, and discuss the potential therapeutic effects of TNF-alpha upon these cells in tumor growth and some inflammatory disorders.
基金：
National Natural Science Foundation of China; Program for Huazhong University of Science and Technology Academic Frontier Youth Team [81800355, 81873506]; [2019QYTD08]
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Internal Med,Dept Cardiol,Wuhan 430030,Peoples R China[2]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Hubei Key Lab Genet & Mol Mech Cardiol Disorders,Wuhan 430030,Peoples R China
通讯作者：
通讯机构：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Internal Med,Dept Cardiol,Wuhan 430030,Peoples R China[2]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Hubei Key Lab Genet & Mol Mech Cardiol Disorders,Wuhan 430030,Peoples R China
推荐引用方式(GB/T 7714)：
Yu Kun,Yu Chengxin,Jiao Liping,et al.The Function and Therapeutic Implications of TNF Signaling in MDSCs[J].BIOMOLECULES.2022,12(11):doi:10.3390/biom12111627.
APA：
Yu, Kun,Yu, Chengxin,Jiao, Liping,Miao, Kun,Ni, Li...&Zhao, Chunxia.(2022).The Function and Therapeutic Implications of TNF Signaling in MDSCs.BIOMOLECULES,12,(11)
MLA：
Yu, Kun,et al."The Function and Therapeutic Implications of TNF Signaling in MDSCs".BIOMOLECULES 12..11(2022)
