单位：[1]Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China.华中科技大学同济医学院附属同济医院外科学系肝脏外科[2]Hubei Key Laboratory of HepatoPancreato-Biliary Diseases, Wuhan, Hubei, P.R. China.[3]Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Health, Wuhan, Hubei, P.R. China.
Transforming growth factor beta (TGF-beta) signaling pathway plays important roles in hepatocellular carcinoma (HCC) progression. Long intergenic non-protein coding RNAs (lincRNAs) are important components of TGF-beta signaling pathway and perform their functions through different mechanisms. Here, we found that LINC02551 was activated by TGF-beta transcriptionally and identified a 174-amino-acid peptide, Jun binding micropeptide (JunBP), encoded by LINC02551 in HCC tissues and HCC cell lines. Functional study showed that JunBP promotes HCC metastasis through binding to c-Jun and subsequent promotion of its phosphorylated activation. Activated c-Jun has higher binding affinity to SMAD3, which in turn leads to more SMAD3 recruited to the promoter region of LINC02551. We find a positive feedback among them, and this mechanism provides a novel potential prognostic biomarker and therapeutic target in HCC.
基金：
This work was supported by The National Natural Science Foundation of China (No.
81572855 to XC, No. 81572427 and No. 81874189 to BZ, and No. 82103597 to ZL) and Graduates’ Innovation Fund, Huazhong University of Science and Technology (No.
5003540055 to ZL).
第一作者单位：[1]Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China.[2]Hubei Key Laboratory of HepatoPancreato-Biliary Diseases, Wuhan, Hubei, P.R. China.
共同第一作者：
通讯作者：
通讯机构：[1]Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China.[2]Hubei Key Laboratory of HepatoPancreato-Biliary Diseases, Wuhan, Hubei, P.R. China.[3]Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Health, Wuhan, Hubei, P.R. China.
医学