The early detection of pancreatic ductal adenocarcinoma (PDAC) dramatically improves outcome. All available state-ofthe-art imaging methods allow early detection with EUS being the best technique for exclusion of PDAC and detection of very early PDAC. Etiological differentiation of small SPL is important to guide individually tailored patients??? management including radical surgery in resectable PDAC, medical (neoadjuvant or palliative intended) treatment in patients with non-resectable malignancy, pancreatic parenchyma saving strategies in some non-PDAC, and follow-up in particular in low-grade PanNEN or other small benign lesions. Multimodality EUS imaging including B-Mode assessment, elastography, contrast-enhancement and EUS-guided sampling is the most appropriate technique for diagnosis and risk assessment of small SPL. We present a review discussing modern (endoscopic) ultrasound imaging techniques including contrast enhanced ultrasound and elastography for the early detection and characterization of solid pancreatic lesions. (Cite this article as: Dietrich CF, Shi L, Koch J, L??we A, Dong Y, Cui X, et al. Early detection of pancreatic tumors by advanced EUS imaging. Minerva Gastroenterol 2022;68:133-43. DOI: 10.23736/S2724-5985.20.02789-0)